血清Cys-C、β_2-MG、RBP在2型糖尿病肾病早期诊断中的价值

The early diagnostic value of serum Cys-C、β_2-MG、RBP in patients with diabetic nephropathy

目的探讨血清Cys-C、RBP、β_2-MG在2型糖尿病肾病早期诊断中的应用价值。方法根据尿白蛋白排泄率UAER将90例2型糖尿病患者分为3组,即正常组、微量组、大量组,对90例观察组和30例健康对照组的血清同时进行了Cys-C、β_2-MG、RBP、BUN、Crea 5项目平行检测,并作对比分析。结果微量组和大量组Cys-C、β2-MG、RBP 3项目结果与健康对照组比较均有非常显著增高,正常组与健康对照组比较差异无统计学意义。大量组阳性率分别为100%、100%、96.1%;微量组阳性率Cys C(92.3%)>β_2-MG(84.6%)>RBP(66.6%)>Crea(46.1%)>BUN(28.2%)。结论血清Cys-C、β_2-MG、RBP在2型糖尿病肾病早期诊断中有较高的阳性检出率,可作为糖尿病肾病早期诊断指标,尤其以Cys-C为理想指标。

Objective To evaluate the Cys-C.β2-MG,RBP as marker 三 of early diagnosis in patients with diabetic nephropathy Ⅱ （DN）. Methods ninety patients with DN were divided into three groups according to urinary albumin excretion rate （UAER） ,that is normal, micro and mass group. Serum Cys-C、β2-MG,RBP.BUN.Crea were detected and parallelly contrasted in the three groups and control group with thirty healthy people. Results compared with the control group,the serum Cys-C、β2-MG, RBP of micro and mass group both significantly increased and the normal group had no significant difference. The positive rate of Cys-C、β2-MG.RBP in mass group was respectively 100%. 100%.96.1%;the positive rate in micro group as follows： Cys C （92.3%）〉B2-MG（84.6%）〉RBP（66.6%）〉Crea（46. 1%）〉BUN（28.2%）. Conclusion serum Cys-C、β2-MG.RBP have high positive rates in patients with diabetic nephropathy Ⅱ （DN）. They can be used as early diagnostic marker of diabetic nephropathy Ⅱ especially Cys-C.