卡托普利对前壁心肌梗塞近远期预后的影响

The late and long-term effect of captopril for Ant.wall acute myocardial infarction′s prognosis.

目的：了解血管紧张素转换酶抑制剂（ＡＣＥＩ）类卡托普利对前壁心肌梗塞近远期预后的影响。方法：将急性前壁心肌梗塞患者发病入院时随机分为卡托普利治疗组１０６例（甲组）和安慰剂组１１４例（乙组），治疗期４周内及一年后随访情况进行比较。结果：甲组的心室功能损害程度较乙组轻，近期的病死率低于乙组（Ｐ＜００５），心肌梗塞后心绞痛，再梗塞发生率及远期病死率均低于乙组（Ｐ＜００５）。

Objective:To understand the late and long-term effect of captopril-Angiotension thansferase inhibitor for acute Ant.wall myocardial infarction′s prognosis.Methods:Patients with Ant.Wall AMI were divided randomizedly into two group.106 cases of Ant.wall AMI(Group I) were treated with captopril for four weeks,114 cases served as placento group (Group Ⅱ)。The result was comparved after four weeks and one year fallowing up.[WT5”HZ]Results:The damage of ventrcular function in group I was slighter than that in group Ⅱ.The late-term motality was lower in group Ⅱ (P<0 05).The incidence of angina pectorls.reinfarction and the motality farther on were all lower than that in group Ⅱ(P<0 05).Conclusions:Early application of captopril can improve the late and long-term prognosis.