绞股蓝治疗脑梗塞后脑功能障碍的诱发电位研究

Study of PRVEP about effects of gynostemma pentaphyllum on brain dysfunction of patients after brain infarction

目的采用视觉诱发电位（PRVEP）研究绞股蓝对脑梗塞病人脑功能障碍的改善作用。方法32例脑梗塞患者（A组）及正常老年人（C组）服用绞股蓝，并设立脑复康治疗组（B组）作为对照，三组均服药12周;其中有18例脑梗塞患者服用绞股蓝24周;服药前、后分别测查PRVEP的潜伏期、波幅、主波群形态和各波出现率等指标。结果A、C组被试在服用绞股蓝后，PRVEP主波群形态变陡，各波出现率增多，尤其晚成分N3、P4、N4波改善明显，C组晚成分波潜伏期缩短。服用绞股蓝24用较12周对改善PRVEP更明显。结论绞股蓝可明显改善脑梗塞病人的脑功能障碍，这为临床上治疗脑梗塞后认知功能障碍提供了可靠的依据。

Objective The experimem was to explore the effects of Gynostemma Pentaphyllum (GP) on cerebral infarction (CI) patients using PRVEP. Methods 32 CI patients (Group A) and matched normal elderly people (Group C) were prescribed GP, the other CI patients were prescribed Piracetam. All subjects took medicine for 12 weeks, 18 subjects of Group A for 24 weeks. Before and after taking medicine, they were assessed by PRVEP. Results After subjects taking GP, the shape of VEP was steeper, and the waves' frequency was increased, especially waves N3.P4 .N4. The latency of the late oomponent waves in Group C was shorter. Also, in Group A, after subjects taking GP for 24 weeks, the scales of VEP were more improved than those of 12 weeks. Conclusions GP can improve the brain function of patients after brain infarction.