精神分裂症及情感性障碍病人的血清微量元素测定

Serum trace elements measurement in patients with schizophrenia and affective disorders

目的探索精神分裂症及情感性障碍病人血清微量元素变化。方法采用原子吸收分光光度计测定精神分裂症（105例）及情感性障碍（29例）血清微量元素含量，并与同地区健康志愿居民（100例）进行对照研究。结果精神分裂症及情感性障碍病人治疗前血清钙、铜、铁均显著增高（P＜0.001），血清镁、锌均显著降低（P＜0.001）;精神分裂症病人治疗四周末及六周末血清镁、锌显著高于治疗前（P＜0.01），治疗六周末，血清钙、铜、铁显著低于治疗前（P＜0.01）;各组血清微量元素的变化均无性别差异（P＞0.05）。结论血清中某些微量元素含量在精神分裂症及情感性障碍发病期与健康者之间存在一定差异。提示精神分裂症及情感性障碍的发病与血清微量元素的改变有关联。

Objective To explore the change of serum trace elements in patients with schizophrenia and affective disorders, and the correlation among level of serum trace elements and the treatment with antipsychotics and other factors. Methods Calcium, magnesium,zinc, copper and iron in serum were measured in 105 patients with schizophrenia and 29 patients with affective disorders, and were compared with that of 100 volunteers as control. Results Serum calcium, copper and iron were increased in patients with schizophrenia and affective disorders (P <0. 001) before treatment. However, serummagnesium, and zinc were decreased in the patients (P <0. 001). At the end of 4th and 6th week after treatment with clozapine or/ and chlorpromazine, serum magnesium and zinc were higher than before treatment (P <0. of). And the other hand, at the end of 6th week after treatment, serum calcium, copper and iron were lower than before treatment (P <0. 01) in patients. Sex difference were not significant on the change of serum trace elements in the patient groups. Conclusions There are differences in serum trace elements between normal controls and patients with schizophrenia or affective disorders. It suggested that these changes of serum trace elements were related to the onset of schizophrenia and affective disorders.