非那雄胺疗程对良性前列腺增生组织中VEGF表达及MVD计数影响的变化

The Influence of Finasteride on BPH-related Microvessel Density and Vascular Endothelial Growth Factor Expression

目的通过在前列腺电切(TURP)术前不同时间应用非那雄胺,观察对良性前列腺增生(benignprostate hyperplasia,BPH)组织的微血管相关因素的影响变化,以寻求最佳用药时间。方法将拟行TURP的BPH患者270例,随机分为5组。用药组分别在术前不同时间服用非那雄胺,记录术中出血量;术后检测前列腺组织微血管密度(MVD)和血管内皮生长因子(VEGF)表达。结果对照组术中平均出血量、前列腺组织MVD值、VEGF阳性计数与各实验组比较,P>0.05;与实验2组比较,P<0.05;与实验3组、4组比较,P<0.01。实验2组与3组比较,P<0.05;实验3组与4组比较,P>0.05。结论术前服用非那雄胺2周可减少前列腺组织内血管生成,并可减少TURP术中出血,服药3周效果最佳。

Objective By application of finasteride at different times before the TURP{ transurethral prostatic resection} surgery to observe the BPH-related factors microvascular changes,so as to find the best medication time. Methods Two hundred and seventy patients were randomly divided into 5 groups. The treatment group were taken finasteride at different times before surgery,and the blood loss was recorded in the operation;The microvessel density { MVD } and expression of vascular endothelial growth factor（VEGF） of prostate tissue were detected. Results The average intr- aoperative blood loss, prostate tissue MVD values and VEGF-positive count of the control group were compared with each group. There was statistical significance between the control group and the group 2 （ P 〈 0.05 ） , group 2 and 3 （ P 〈 0. 05 ）, the control group and the group 2 and 3 （ P 〈0.01 }. There was no statistical significance between group 3 and 4{ P 〉0.05）. Conclusion Taking finasteride for two weeks before the surgery can reduce angiogenesis in prostate tissue and blood loss during TURP;The best medication times is three weeks.