3,5-二甲基-4-羟基苯甲腈的合成研究

A study on synthesis of 3,5-dimethyl-4-hydroxybenzonitrile

以3,5-二甲基-4-羟基苯甲醛和盐酸羟胺为原料,分别在甲酸、乙酸和N,N-二甲基甲酰胺(DMF)中一步反应合成了3,5-二甲基-4-羟基苯甲腈。以DMF为溶剂的反应效果最好,最佳条件下收率达90%以上,粗品含量98%以上。

A one-pot synthesis of 3,5-dimethyl-4-hydroxybenzonitrile from 3,5-dimethyl-4-hydroxybenzaldehyde and hydroxyamine hydrochloride in solvents such as formic acid, acetic acid, and N, N-dimethylformamide （DMF） is studied. The yields are optimal if in DMF, and the optimization of reaction conditions is carried out. Under such optimum conditions the yield of the nitrile can be 93% ,with purity of above 98% ,which are determined by HPLC.