绿茶多酚防治老年神经退行性疾病研究进展

Review on the neuroprotective effects of Green tea polyphenols for the treatment of neurodegenerative diseases

老年神经退行性疾病如帕金森病和阿尔茨海默病等均为多病因的复杂性疾病,在临床上单一作用靶点的药物治疗效果有限。绿茶多酚以其清除自由基、鳌合金属离子和调节神经细胞内蛋白激酶通路等作用在老年神经退行性疾病的防治中具有很大的潜力,本文就近年来该方面的研究进展进行阐述。

Considering the multi-etiological characters of neurodegenerative disorders such as Parkinson＇s disease and Alzheimer＇s disease,the current pharmacological approaches using drugs oriented towards a single molecular target possess limited ability to modify the course of the diseases.Green tea polyphenols have been reported to possess more than two active neuroprotective-neurorescue moieties that simultaneously manipulate multiple targets involved in neurodegeneration.This review aims to shed light on the multipharmacological neuroprotective activities and the mechanisms of green tea polyphenols on neurodegenerative diseases.