摘要
为探讨可溶性肿瘤坏死因子受体(sTNFR)与膀胱肿瘤生物学行为的关系,测定了26例膀胱移行细胞癌患者和20例正常对照者血清中(sTNFR)水平。发现膀胱癌患者血清sTNFR显著高于对照组(P<0.001),并随临床分期的增加而升高,术后两周时显著下降(P<0.01)。结果表明sTNFR抑制了血中肿瘤坏死因子的生物学活性而降低了机体的免疫功能,并可作为评估病情严重程度和预后的指标。
The serum levels of sTNFR were detected in 26 cases of urinary bladder carcinoma and 20 normal controls. It showed that the sTNFR levels were increased significantly in patients (P< 0.001) and the increase of serum levels correlated with clinical stages of disease, being dropping down after surgical operations. These results suggest that sTNFR could lessen the immune function of the host by suppressing the activities of TNF,and the detection of sTNFR may be used as a parameter in evaluating the severity and prognosis of disease.
出处
《上海免疫学杂志》
CSCD
北大核心
1998年第6期361-362,共2页
Shanghai Journal of Immunology
关键词
膀胱移行细胞癌
STNFR
测定
Bladder neoplasms
carcinoma
soluble tumor necrosis factor receptor
