丹红注射液治疗血管性痴呆的临床研究及对β-Ap、Apo B的影响

Clinical Observation of Treatment with Dan Hong Injection in Patients with Vascular Dementia and Its Impact on β-Ap and Apo B

目的:观察丹红注射液治疗瘀血阻络型血管性痴呆患者的临床疗效并探讨其作用机制。方法:治疗组予以丹红注射液,对照组给予银杏达莫注射液,两组均给予基础治疗,疗程均为28d。结果:治疗后两组的MMSE、ADL积分与治疗前相比较(P<0.01)。治疗组明显优于对照组(P<0.05)。治疗后两组中医证候积分与治疗前比较(P<0.01),治疗组优于对照组(P<0.05);两组血液流变学指标治疗前后比较均有明显降低(P<0.01)。治疗后两组血清β-Ap、ApoB的含量较治疗前明显降低(P<0.01)。结论:丹红注射液治疗VD有较好的疗效,在改善患者中医证候方面作用优于银杏达莫注射液;其作用机制可能与丹红注射液具有降低血浆粘度、纤维蛋白原、血清β-Ap的含量,从而减轻β-Ap对神经细胞的毒性作用;降低血清ApoB的含量,纠正脂蛋白代谢紊乱有关。

Objective：To observe the clinical efficacy of dan hong injection on treating patients with vascular dementia and explore the mechanism.Method：The treatment group was treated by dan hong injection,while the control group by yin xing da injection,both groups were given basic treatment,28 days a course.Results：After the treatment,compared with MMSE、 ADL scores and Chinese medical syndrome scores of tow groups（P0.01）,treatment group was better than that of control group（P0.05）.The blood rheologic index and contents about β-Ap、ApoB of two groups were all down（P0.01）.Conclusion：It had the better efficacy of dan hong injection on treating VD than yin xing da mo injection.Its mechanism may be related to the decreasin of plasma viscosity,fibrinogen,β-Ap,ApoB,correcting lipoprotein metabolism.