解热镇痛药引起膜性肾病1例报道

One Reported case of Membranous Nephropathy Caused by Antipyretic Analgesics

回顾性分析1例非甾体类解热镇痛药引起膜性肾病病例的诊治过程。患者服用非甾体类解热镇痛药1月后,以下肢浮肿为首发症状,血浆白蛋白明显降低,血脂升高,24h尿蛋白升高,余实验室检查无明显异常,行肾穿刺活检,活检报告为:膜性肾病(Ⅰ)期。予强的松标准疗法及雷公藤多甙片等相关治疗,症状缓解,24h尿蛋白明显降低。非甾体类解热镇痛药引起的膜性肾病非常少见,建议应据药物安全性和患者危险因素谨慎用药。

A retrospective analysis of diagnosis and treatment of 1 case of membranous nephropathy caused by non-steroidal anti-inflammatory drugs.After the patients took non-steroidal anti-inflammatory drugs for one month,lower extremity edema appeared as the first symptom,serum albumin decreased significantly,blood lipids elevated,24h urine protein increased and there were no significant laboratory abnormalities.The renal biopsy reported membranous nephropathy periodⅠ.Prednisone standard therapy and tripterygium wilfordii tablets and other related treatment were given with symptom relieved and 24h urine protein decreased significantly.Membranous nephropathy caused by Non-steroidal anti-inflammatory drugs was extremely rare,so it is recommended to be used with caution according to drug safety and risk factors in patients.