摘要
有序介孔材料具有较高的比表面积、孔体积和可调控的孔道结构,被广泛应用为药物控释的载体。综述了不同种类有序介孔材料载体的药物控释行为及其影响因素:有序介孔材料经表面改性处理后,能改善其对药物控释的能力,包括提高药物负载量以及减缓药物释放速率。通过控释,药物的药效持久性和治疗效果得以提高,并能实现靶向给药。对其应用前景进行了展望。
Ordered mesoporous materials have been widely employed as carriers for controlled drug release due to their high specific surface areas,pore volumes and regulated pore channels.The controlled drug release capacities of ordered mesoporous materials can be improved upon surface modification,such as drug loading amount and enhancement and drug release rate reduction.The controlled drug release can improve the drug persistent efficacy and therapeutic efficiency,and achieve targeted drug delivery.Different ordered mesoporous materials as carriers for controlled drug release and influence factors are reviewed,and their application prospects are predicted.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2010年第4期677-682,共6页
Chemical Industry and Engineering Progress
基金
国家自然科学基金(20976100)
山东省自然科学基金重点项目(Z2006B07)
济南市留学人员创业计划(20080309)
关键词
有序介孔材料
药物控释
载体
改性
ordered mesoporous materials
controlled drug release
carriers
modification
