顺铂与香菇多糖胸腔灌注治疗恶性胸腔积液临床观察

Observation in the Treatment of Malignant Pleural Effusion by Injection to Cavity with Lentinan Cispiatinum

目的:观察顺铂与香菇多糖胸腔灌注治疗恶性胸腔积液的疗效与毒副反应的差异。方法:30例恶性胸腔积液患者随机分为A、B两组,给予胸腔内灌注顺铂或香菇多糖,每周1次,连续2-3周。观察两组治疗前后胸腔积液控制情况,生活质量改善及毒副反应情况。结果:A、B两组总有效率分别为60%和73.3%(P>0.05),80%和86.7%(P>0.05)患者提高了生活质量。A组及B组患者毒性反应均轻微,可耐受。结论:顺铂与香菇多糖胸腔灌注治疗恶性胸腔积液的疗效均显著,可明显改善患者生活质量,毒副反应轻微,可耐受。

Objective ：To observe clinical therapeutic effec- tiveness and adverse reaction in the treatment of malignant pleu- ral effusion by injection to cavity with DDP or lentinan. Methods：Thirty patients with malignant pleura] effusion were divided into two groups ： in the group A, DDP were used, while in the group B lentinan, was injected. Both were given once a week for consecutive 2- 3weeks. therapeutic effect, life quality and adverse reactions were observed. Results ：The overall objective responded rate was 60.0% and73.3% （ P 〉 0. 05 ） respective. There are 80% and 86. 7% （ P 〉 0.05 ） patients in the two groups respective proved their life quality. The incidence of adverse reactions were lower in both two groups. Conclusion： Both DDP and lentinan are effective for malignant pleural effusion with mild side effects.