帕瑞昔布钠用于泌尿外科腹腔镜术后镇痛效果的观察

The Postoperative Analgesic Effects of Parecoxib for Laparoscopic Urological Surgery

目的观察帕瑞昔布钠用于泌尿外科腹腔镜术后镇痛的效果及不良反应。方法40例ASAI～Ⅲ级的患者行择期泌尿外科腹腔镜手术，随机分为两组：氟比洛芬酯组（Ⅰ组，n=20）：手术结束后2h静脉给予氟比洛芬酯100mg，随后100mg／12h持续3天；帕瑞昔布钠组（Ⅱ组，n=20）：手术结束后2h静脉给予帕瑞昔布钠domg，随后40mg／12h持续3天。观察两组术后2h、4h、16h、24h、d8h的VAS评分及恶心、呕吐等不良反应的发生率。结果两组患者术后2h的VAS评分平均值在4～5分之间，其他时间点在0～3分的范围。两组术后VAS评分的差异无统计学意义。结论帕瑞昔布钠可以有效缓解中等程度的术后疼痛且不良反应的发生率低，是泌尿外科腹腔镜手术较为理想的术后镇痛药物。

Objective To evaluate the postoperative analgesic effects of parecoxib for laparoscopic urological surgery. Methods Forty patients with ASA scale of Ⅰ to Ⅲ underwent laparoscopic urological surgery were randomly divided into two groups ： the flurbiprofen group （group Ⅰ , n =20） with IV flurbiprofen 100 mg at 2 hours after operation, and 100 mg twice a day during 3 days after operation; and the pareeoxib group （ group Ⅱ , n. = 20） with IV pareeoxib 40 mg at 2 hours after operation, and 40 mg twice a day during 3 days after operation. The VAS score at 2,4,16,24 and 48 hours after operation and the adverse effects were recorded. Results The average VAS score of the two groups was 4 to 5 at 2 hours after operation, and was 0 - 3 at other time points. There was no significant difference among two groups in the VAS score. Conclusion Parecoxib can provid effective postoperative analgesia for patients underwent laparoscopic urological surgery as flurbiprofen.