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X连锁精神发育迟滞相关基因JARID1C研究进展 被引量：2

Progress on X-linked mental retardation related gene JARID1C
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摘要 JARID1C基因属于X连锁精神发育迟滞相关基因之一,其表达产物影响大脑神经系统中相关基因的转录和表达,并可能与人类认知能力密切相关。对JARID1C基因功能的研究有助于理解该基因在精神发育迟滞形成和人类认知能力发展中的分子作用,也能为精神发育迟滞的临床诊断和防治提供参考。文章对JARID1C基因的定位、分离、转录产物的生理功能及其认知功能做一综述,并对以后的研究工作进行了展望。 JARID1C is one of the genes related to X-linked mental retardation. Its express product influences transcription and expression of the related genes in brain nervous system, and may be associated with human cognitive ability. Study on the functions of JARID1C not only helps to understand its molecular role in mental retardation and human cognitive ability, but also provides references for clinical diagnosis and prevention of mental retardation. This article reviews the progresses on JARID1C in location, isolation, physiological functions, and cognitive fimctions of its encoding product. The future research work of JARID1C is also discussed.
作者 雷徐 高晓彩 张富昌
机构地区 西北大学生命科学学院人口与健康研究所
出处 《遗传》 CAS CSCD 北大核心 2010年第3期205-210,共6页 Hereditas（Beijing)
基金 陕西省科技研究发展计划项目(编号:2007K01-25)资助
关键词 JARID1C基因 精神发育迟滞 认知能力 基因突变 JARID1C gene mental retardation cognitive ability gene mutation
分类号 R749.94 [医药卫生—神经病学与精神病学]
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参考文献35

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