蛇葡萄素对人胃癌细胞SGC-7901裸鼠移植瘤生长的抑制作用

Anti-tumor Effects of Ampelopsin on Human Gastric Cancer SGC-7901 Implanted in Nude Mice

目的观察蛇葡萄素(APS)体内抗人胃癌作用。方法采用人胃癌细胞裸鼠移植瘤模型,将裸鼠随机分成5组,APS三个剂量连续灌胃给药10天,观察肿瘤体积、相对肿瘤体积(RTV)、相对肿瘤增殖率(T/C)、瘤重、抑瘤率(IR),以此评价APS的抗肿瘤作用。结果在人胃癌细胞株SGC-7901裸鼠移植瘤的抑瘤实验APS600mg/kg、300mg/kg、150mg/kg灌胃给药10天,其相对肿瘤增殖率为52.84%、71.12%、62.14%,其抑瘤率分别为38.8%、27.5%、27.3%。结论APS对人胃癌细胞株SGC-7901裸鼠移植瘤有明显的抑制作用。

Objective To investigate the effects of ampelopsin（APS） on the growth of human gastric cancer cell SGC-7901 in nude mice. Methods SGC-7901 cells were inoculated into the nude mice to establish gastric cancer model. Then the BALB/C nude mice with xenograft tumor were randomized into 5 groups. The ampelopsin was administered at 3 dosages by irrigate the stomach daily for 10 d. The anti-tumor effects of ampelopsin was evaluated based on the tumor volume, relative tumor volume（RTV）, tumor weight,relative tumor proliferative rate （T/C）and tumor inhibition rate（IR）. Results At the 600 mg/kg, 300 mg/kg, 150 mg/kg dose of APS, the relative tumor proliferation rate was 52.84%, 71.12% and 62. 14%,respectively, and the growth inhibition of the transplanted tumor was 38.8%, 27. 5% and 27. 3%,respectively. Conclusion APS in appears to be a potent anti tumor agent that was firstly discovered in the transplanted human gastric cancer cell SCX2-7901 in nude mice in vivo.