期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

生长分化因子15与心血管疾病——从基础到临床 被引量：2

Growth differentiation factor-15 in cardiovascular disease:from bench to bedside
下载PDF
导出
摘要 生长分化因子-15(growth differentiation factor-15,GDF-15)是转化生长因子β(transforming growth factorβ,TGF-β)超家族成员的一个远支,是一个重要的心血管保护因子。作为新的标志物,GDF-15水平与多种心血管疾病的诊断、危险分层和预后判断有密切关系。本文就GDF-15基因的生物学特点及其在心血管疾病中的多种功能作一综述。 Growth differentiation factor（GDF）-15,a distant member of the transforming growth factor-β cytokine superfamily,is a powerful cardioprotective factor.Many studies have demonstrated that serum GDF-15 level is a novel marker closely associated with the diagnosis,risk stratification,and prognosis of several cardiovascular diseases.This article mainly reviews the characteristics of GDF-15 and its multifunction in cardiovascular diseases.
作者 顾宇英 张代富
机构地区 同济大学附属东方医院心内科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2010年第3期317-320,共4页 Academic Journal of Second Military Medical University
关键词 生长分化因子 转化生长因子β 心血管疾病 危险分层 生化标志物 心肌肥厚 家族成员 再灌注损伤 心肌细胞凋亡 心血管保护 growth differentiation factor-15 transforming growth factor-β cardiovascular diseases
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献22

  • 1Tan M,Wang Y, Guan K, Sun Y. PTGFbeta, a type beta transforming growth factor (TGF-beta) superfamily member,is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway[J].Proc Natl Acad Sci USA, 2000,97 : 109- 114.
  • 2Bootcov M R,Bauskin A R,Valenzuela S M,Moore A G,Bansal M, He X Y, et al. MIC-1, a novel macrophage inhibitory cytokine,is a divergent member of the TGF-beta superfamily. [J]. Proc Natl Acad Sci USA, 1997,94:11514-11519.
  • 3Ago T, Sadoshima J. GDF15, a cardioprotective TGF-beta superfamily protein[J]. Circ Res, 2006,98 : 294-297.
  • 4Bottner M, Laaff M, Schechinger B, Rappold G, Unsicker K Suter-Crazzolara C. Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1(GDF-15/MIC-1 ) [J].Gene, 1999,237:105-111.
  • 5Kempf T, Eden M, Strelau J, Naguib M, Willenbockel C, Tongers J, et al. The transforming growth factor-beta superfamily member growth differentiation factor 15 protects the heart from ischemia/reperfusion injury[J]. Circ Res, 2006,98:351-360.
  • 6Xu J,Kimball T R,Lorenz J N,Brown D A,Bauskin A R,Klevitsky R,et al. GDF15/MIC-1 functions as a protective antihypertrophic factor released from the myocardium in association with SMAD protein activation[J].Circ Res, 2006,98: 342-350.
  • 7Brown D A, Breit S N, Buring J, Fairlie W D, Bauskin A R, Liu T, et al. Concentration in plasma of macrophage inhibitory cytokine 1 and risk of cardiovascular events in women: a nested case control study[J]. Lancet, 2002,359 : 2159-2163.
  • 8Kempf T,Wollert K C. Growth differentiation factor 15:a new biomarker in cardiovascular disease [J]. Herz, 2009, 34: 594- 599.
  • 9Kempf T,Widera C, Bavendiek U. Growth-differentiation factor-IS promotes anti-inflammatory effects and enhances survival after experimental myocardial infarction [J ]. Circulation, 2007, 116:Ⅱ165.
  • 10Wang J,Xu N,Feng X,Hou N,Zhang J,Cheng X,et al. Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure[J]. Circ Res, 2005,97 : 821-828.

同被引文献32

  • 1花苏榕,张抒扬.生长分化因子-15基因多态性的研究进展[J].中华临床医师杂志（电子版）,2011,5(22):6688-6690. 被引量：3
  • 2脑卒中患者临床神经功能缺损程度评分标准（1995）[J].中华神经科杂志,1996,29(6):381-383. 被引量：15761
  • 3Ago T, Sadoshina J. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res, 2006, 98: 294-297.
  • 4TobinJF, Celeste AJ. Bonemorphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease. Drug Discov Today, 2006, 11: 405-411.
  • 5Bauskin AR, Brown DA, Kuffner T, et al. Role of macrophage inhibitory cytokine-1 in tumo- rigenesis and diagnosis of cancer . Cancer Res, 2006, 66: 4983-4986.
  • 6Kempf T, Sinning JM, Quint A, et al. Growth- differentiation factor-15 for risk stratification in patients with stable and unstable coronary heart disease: results from the AtheroGene study. Circ Cardiovasc Genet,2009,2 :286-292.
  • 7Bottner M, Suter-Crazzolara C, Schober A, et al. Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/ macrophage- inhibiting eytokine-l(GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res, 1999,297 : 103-110.
  • 8Wollert KC. Growth-differentiation factor-15 in cardiovascular disease: from bench to bedside, and back . Basic Res Cardiol, 2007, 102:412-415.
  • 9Kempf T, Horn-Wichmann R, Brabant G, et, al. Circulating concentrations of growthdifferentiation factor-15 in,apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assay. Clin Chem, 2007,53 : 284-291.
  • 10Kempf T, Eden M, Strelau J, et al. The transforming growth factor-beta superfamily member growth differentiation factor-15 protects the heart from ischemia/ reperfusion injury. Circ Res, 2006, 98: 351-360.

引证文献2

二级引证文献10

第二军医大学学报
2010年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部