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英夫利西单抗治疗克罗恩病的疗效观察 被引量：4

Efficacy of infliximab in treatment of patients with Crohn's disease
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摘要 目的探讨英夫利西单抗治疗克罗恩病的疗效。方法收集第二军医大学长海医院2007年12月至2009年2月符合诊断标准的克罗恩病患者18例,使用英夫利西单抗进行治疗(5mg/kg静滴0、2、6周,以后每8周1次,维持46周),2周后观察疗效。结果使用英夫利西单抗治疗2周后,患者腹痛、腹泻等症状明显缓解,全身营养状况改善迅速,并发症如瘘管等均愈合良好,未出现明显不良反应,其中CDAI评分从321.5±34.5降为98.0±25.1(P<0.05);ESR(mm/h)从43.6±18.6(25～76)下降为6.8±3.1(P<0.05)。结论英夫利西单抗治疗克罗恩病具有确切的近期疗效且有很好的安全性,但远期疗效尚有待观察。
作者 孙怡燕 吴永发 徐灿 邹多武 周国武 李兆申
机构地区 江苏省江阴市人民医院消化内科 第二军医大学长海医院消化内科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2010年第3期338-339,共2页 Academic Journal of Second Military Medical University
关键词 英夫利西单抗 抗肿瘤坏死因子 克罗恩病
分类号 R574.622 [医药卫生—消化系统]
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参考文献9

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同被引文献40

  • 1王莉莎,黄烽,张江林,张莉芸,邓小虎,张亚美,李晓峰,郭军华.肿瘤坏死因子拮抗剂治疗类风湿关节炎和强直性脊柱炎发生结核的风险[J].中华风湿病学杂志,2006,10(10):607-610. 被引量：18
  • 2欧阳钦,胡品津,钱家鸣,郑家驹,胡仁伟.对我国炎症性肠病诊断治疗规范的共识意见[J].胃肠病学,2007,12(8):488-495. 被引量：751
  • 3Renato Caviglia,Mentore Ribolsi,Marina Rizzi,Sara Emerenziani,Maria Laura Annunziata,Michele Cicala.Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up[J].World Journal of Gastroenterology,2007,13(39):5238-5244. 被引量：14
  • 4Targan SR,Hanauer SB,van Deventer SJ,et al.A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn’s disease.Crohn’s Disease cA2 Study Group[J].N Engl J Med,1997,337(15):1029-1035.
  • 5Hanauer SB,Feagan BG,Lichtenstein GR,et al.Maintenance infliximab for Crohn’s disease:the ACCENT I randomised trial[J].Lancet,2002,359(9317):1541-1549.
  • 6Rutgeerts P,Sandborn WJ,Feagan BG,et al.Infliximab for induction and maintenance therapy for ulcerative colitis[J].New Engl J Med ,2005,353(23):2462-2476.
  • 7Schnitzler F,Fidder H,Ferrante M,et al.Long-term outcome of treatment with infliximab in 614 patients with Crohn’s disease:results from a single-centre cohort[J].Gut,2009,58(4):492-500.
  • 8Kraemer M,Kirschmeier A,Marth T.Perioperative adjuvant therapy with infliximab in complicated anal Crohn’s disease[J].Int J Colorectal Dis,2008,23(10):965-969.
  • 9De Ridder L,Rings EH,Damen GM,et al.Infliximab dependency in pediatric Crohn’s disease:long-term follow-up of an unselected cohort[J].Inflamm Bowel Dis,2008,14(3):353-358.
  • 10Arhur B,Miguel R.Biologic therapy in the management of extraint estinal manifestations of inflammatory bowel disease[J].Inf lam m Bow el Dis,2007,13:1424-1429.

引证文献4

二级引证文献11

第二军医大学学报
2010年 第3期

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