微生态制剂治疗新生儿高胆红素血症疗效观察

The Therapeutic Effect of Microecological Preparation on Neonatal Hyperbilirubinemia

目的:观察微生态制剂治疗新生儿高胆红素血症的效果。方法:将78例新生儿高胆红素血症住院患儿随机分为两组(治疗组48例,对照组30例),均给予针对原发病治疗及蓝光治疗,治疗组加服微生态制剂双歧三联活菌胶囊(贝飞达)。在治疗前、治疗第4 d、第7 d分别检测血清总胆红素水平,并记录蓝光治疗次数及时间。结果:治疗组与对照组在治疗第4 d血清总胆红素比较差异无统计学意义[分别为(202.17±60.62)和(213.62±65.39)μmol/L],在治疗第7 d血清总胆红素较对照组低[分别为(121.69±41.12)和(146.48±51.94)μmol/L,P<0.05];治疗组和对照组血清总胆红素下降值在治疗第4 d分别为(130.96±63.57)和(98.93±62.35)μmol/L(P<0.05)及第7 d分别为(212.90±76.35)和(171.36±67.61)μmol/L(P<0.05);治疗组蓝光治疗次数分别为(2.21±0.87)人次和(2.70±0.95)人次(P<0.05),蓝光时间分别为(39.65±16.51)h和(52.20±19.32)h(P<0.05)。结论:采用微生态制剂治疗新生儿高胆红素血症可使黄疸消退时间明显缩短,并且可以减少蓝光治疗的次数及时间,可作为治疗新生儿高胆红素血症的辅助药物。

Objective：To observe the therapeutic effect of microecological preparation in reducing the serum bilirubin level in neonatal hyperbilirubinemia. Methods： Seventy eight neonates with hyperbilirubinemia were randomly divided into two groups （the therapy group of 48 cases and the control group of 30 cases）. Microecological preparation was given to the therapy group. Total serum bilirubin level was measured before and the 4th and 7th day during the treatment, and the times and duration of phototherapy were recorded. Results： Total serum bilirubin levels had no significant difference on the 4th day （202.17± 60.62 vs 213.62 ± 65.39 μmol/L） between two groups and the total serum bilirubin level of the therapy group was significantly lower than that of the control group on the 7th day （ 121.69 ±41.12 vs 146.48 ± 51.94 μmol/L, P 〈 0.05 ）. The decreased serum bilirubin level of the therapy group was significantly higher than that of the control group on the 4th （130.96 ± 63.57 vs 98.93 ± 62.35 μmol/L, P 〈 0.05 ） and 7th day （212.90 ± 76.35 vs 171.36 ± 67.61 μmol/L, P〈0.05） during treatment. The times （2.21 ±0.87 vs 2.70±0.95, P〈0.05） and duration （39.65±16.51 vs 52.20±19.32 h, P 〈0.05）of phototherapy of the therapy group was significantly lower than that of the control group. Conclusions： Microecological preparation can reduce the serum bilirubin level in neonatal hyperbilirubinemia, and decrease the times and duration of phototherapy. Mieroecological preparation can be used as an assistant medication of neonatal hyperbilirubinemia.