卵黄免疫球蛋白的应用进展

Application Progress on the Yolk Immunoglobulin

卵黄免疫球蛋白是一种来源丰富的多克隆抗体。由于卵黄抗体不能激活哺乳动物的补体系统,不与哺乳动物的Fc受体、类风湿因子、葡萄球菌蛋白A和葡萄球菌蛋白G结合,因而作为诊断试剂具有较高的敏感性。卵黄抗体具有良好的免疫活性,作为防治药物具有见效快,疗效高,无毒副作用,无残留等优点,目前卵黄抗体已得到了广泛应用。本文综述了卵黄抗体在动物病毒性疾病、细菌性疾病和寄生虫病诊断、预防和治疗等方面的应用及前景。

The yolk immunoglobulin is a rich sources of polyclonal antibodies.The yolk immunoglobulin can not activate the complement system of mammalian, and it can not be combined with mammalian Fc receptors, rheumatoid factor, staphylococcal protein A and Staphylococcus protein G. Therefore it has a high sensitivity as a kind of diagnostic reagents. The yolk immunoglobulin has good immune activity.As a prevention drug, it has high efficacy, non-toxic side effect, non-residue. At present, The yolk immunoglobulin as a specific, efficient and inexpensive biological agent has been widely used in animal diseases. In this paper, the application and prospect were reviewed such as diagnosis, prevention and treatment in animal viral, bacterial and parasitic diseases.