摘要
目的探讨冠心病患者体外循环冠脉旁路移植术中使用磷酸肌酸对心肌保护的效果。方法100例冠心病择期行体外循环冠脉旁路移植术患者,随机分为试验组与对照组各50例,试验组术中给予磷酸肌酸钠250mg,对照组不给磷酸肌酸钠。观察体外循环时间、阻断时间、心脏复跳情况、正性肌力药使用情况、ICU停留时间以及围术期心肌梗死和脑卒中等临床指标。两组分别于手术开始前、手术结束时、手术后6小时、12小时和24小时采集患者中心静脉血,检测红细胞压积、肌酸激酶、肌酸激酶同工酶和乳酸脱氢酶。结果试验组体外循环后心脏自动复跳率高,两组术后心肌酶谱均较术前升高,但试验组显著低于对照组。结论冠心病患者围术期应用磷酸肌酸具有一定的心肌保护作用。
Objective The aim of this study was to evaluate the cardioprotective effects of phosphocreatine in patients receiving on-pump coronary bypass surgery.Methods A total of 100 consecutive coronary artery disease patients who were performed selective CABG procedure were randomly assigned to two groups：phosphocreatine group （n=50） and control group （n=50）.The trial group was administered phosphocreatine 250 mg via the central vein catheter before the operation.Those recorded were CPB time,aortic clamping time,rate of spontaneous beating,ICU stay,postoperative hospital stay,perioperative myocardial infarction and in-hospital motality.Blood samples were collected at 5 time points（pre-operation,at the end of operation,6 hours,12 hours and 24 hours operatively） to measure the plasma concentration of creatine kinase,creatine kinase-MB and lactate dehydrogenase.Results The rate of spontaneous beating in the study group is higher than that in the control group.The levels of myocardial enzymes were significantly higher postoperatively comparing with baseline values,whereas were significantly lower in phosphocreatine group than in control group.Conclusion Creatine phosphate revealed effective myocardial protection effects in patients receiving on-pump coronary bypass surgery.
出处
《中国分子心脏病学杂志》
CAS
2010年第1期44-47,共4页
Molecular Cardiology of China
