视神经损伤再生修复的视觉诱发电位研究

VEP research about regeneration repair after optic nerve injury

目的探讨视神经损伤后不同时期视觉诱发电位检查的刺激模式空间频率、P100波幅变化与视神经损伤再生修复之间的联系,探讨将视觉诱发电位技术应用于视神经损伤再生修复评估的可行性。方法分析因眼外伤致视神经受损23例(29眼)的视觉诱发电位资料,实验确定刺激模式空间频率及P100波幅作为检测指标,以受检者的视力表视力为参照,记录全部受检眼的检测结果,在此基础上,分析视神经损伤后不同时期视觉诱发电位变化与视神经再生修复之间的关系。结果一定的视觉刺激模式空间频率大小与视神经损伤再生修复表现出一致性,P100波幅与视力水平呈正相关。视神经损伤后前3个月,再生修复眼视觉诱发电位检测结果呈现动态变化,如视力恢复、刺激模式空间频率减小及P100波幅增大预示视神经损伤再生修复;若视力减退、刺激模式空间频率增大(或无变化)及P100波幅减小(或无变化)则提示视神经损伤严重,无明显再生修复。结论视觉诱发电位技术可用于视神经损伤再生修复的客观评估。

Objective To discuss to the relations between space frequency of stimulation mode, amplitude of P100 and regeneration repair after optic nerve injury. And evaluate the VEP examination on the assessment of repairment of optic nerve injury. Methods Firstly determined space frequency of stimulation mode and amplitude of P100 as examining targets. The visual acuity was taken as references. The relations between VEP changes and regeneration repair on different time stage after optic nerve injury were analyzed. Resuits The space frequency of stimulation mode and the optic nerve regeneration displayed consistency, the amplitude of P100 and present vision level was related. In the first three months after optic nerve injury, VEP results showed dynamic changes which optic nerves were under the circumstances of regeneration repair. It indicated regeneration repair that the visual acuity recovered, space frequency of stimulation mode reduced and amplitude of P100 increased. If the visual acuity fallen, the space frequency of stimulation mode increased （or had no change） and the amplitude of P100 reduced （or had no change）, it indicated that there was not obvious regeneration repair after optic nerve injury. Conclusion VEP can be used to assess the regeneration repair after optic nerve injury.