NAD^+和Nampt与SIRT1的研究进展

The Research Progression of NAD^+,Nampt and SIRT1

热量限制可以引起细胞、生物体寿命延长和降低衰老相关疾病的发生。沉默信息调节因子2在酵母和果蝇中已被证实是热量限制引发长寿效果的关键,在哺乳类动物中的名字是沉默信息调节因子1(SIRT1)。最近,SIRT1的激活物烟酰胺腺嘌呤二核苷酸(NAD+)成了研究中心,因为它很可能是连接细胞及生物体的能量代谢和热量限制导致延缓衰老中枢。与NAD+相关的还有NAD+的限速酶尼克酰胺磷酸核糖转移酶(Nampt)和细胞能量调节因子腺苷酸活化蛋白激酶及NAD+下游因子Sir2-相关酶类(sirtuins)家族成员。它们之间的关系研究的最终结果就很可能解释在哺乳类动物中热量限制的奥秘,从而为今后以此为靶点的药物开发奠定良好的基础。

Calorie restriction（CR） can make organism and cell have a long life and decrease the diseases which is relate to aging. Sir2,which was proved to play a key role in yeast and fly＇s CR,is named SIRT1 in mammalian. Recent research have put NAD^＋ , the activator of SIRT1, in center, because it may the connection of cell and organism＇s energy metabolize and the centre of aging, Nampt, NAD^＋ rate-limiting enzyme, cells＇ energy regular factor AMPK and NAD ^＋ downstream family Sirtuins, was also related to the NAD^＋ . The final conclusion of their interaction may explain the secret of CR in mammalian.