N-乙酰基转移酶2基因多态性研究进展

Research Progress on Polymorphism of N-acetyltransferase 2

N-乙酰基转移酶2是人体内重要的Ⅱ相代谢酶,可催化芳香胺类和杂环胺类物质的乙酰化过程。我国人群中NAT2基因以快乙酰化基因表型为主,最常见的基因型为NAT2*4A、NAT2*6A、NAT2*7B。NAT2慢乙酰化代谢基因型与膀胱癌的发生相关,与异烟肼所致的药物性肝炎相关。研究NAT2基因多态性对评价肿瘤的发生、判断预后及指导药物个体化治疗、减少或减轻药物不良反应有着重要的意义。

N-acetyhransferase 2 is an important phase II metabolizing enzyme, which participate in acetylation process of aromatic amines and heterocyclic amines. The main phenotype of NAT2 gene is rapid acetylation ,the main genotype is NAT2 ＊ 4A, NAT2 ＊ 6A ,NAT2 ＊ 7B in Chinese population. The slow acetylation of NAT2 is associated with the occurrence of bladder cancer and isoniazid-induced hepatitis. Studing the polymorphism of NAT2 gene is important to evaluate the occurrence and prognosis of cancer and to give advice for individualized drug treatment, to reduce or mitigate adverse drug reactions.