摘要
近年来,世界各国儿童和青少年的肥胖发病率逐年增高。而肥胖的一个严重后果是造成胰岛素抵抗。胰岛素抵抗的评价方法包括:瘦素、脂联素、Ghrelin、视黄醇-结合蛋白4等脂肪细胞因子和结合蛋白的测定,高胰岛素正常血糖钳夹试验、微小模型分析的频繁采样静脉血糖耐受试验、空腹血糖和空腹胰岛素比值等生化评价方法。然而,对于儿童,由于许多生化指标分布的正常数据还没有建立,故而没有特异的切点值可用来准确诊断胰岛素抵抗。因此,临床应用时需多种方法综合考虑。
In recent years,the incidence of children and adolescences obesith has increased dramatically.The one serious result of obesity is insulin resistance（IR）.There are many methods for evaluation of IR,including measurement of leptin,adiponectin,Ghrelin,retinol-binding protein-4 etc.adipocytokines and hyperinsulinemic-euglycemic clamp,minimal model analysis of a frequently sample intravenous glucose tolerance test,ratio of fast plasma glucose and fast plasma insulin etc.biochemical markers.No normative data exist for the distribution of these biochemical markers in childhood,and no specific cutoff values are available to make the diagnosis of IR with accuracy.Many methods are to be considered comprehensively in clinics.
出处
《医学综述》
2010年第7期1049-1051,共3页
Medical Recapitulate
关键词
儿童
胰岛素抵抗
评价
Children
Insulin resistance
Evaluation
