肠道感染后IBS与SERT基因多态性关系

RELATIONSHIP OF IBS AND SERT POLYMORPHISM AFTER INTESTINAL INFECTION

目的探讨SERT基因多态性在肠道感染后IBS中的意义。方法用PCR方法对100例健康对照和231例肠道感染后IBS患者SERT基因的VNTRs和5-HTTLPR区多态性进行研究。结果5-HTT’LPR区:肠道感染后C-IBS组L/L基因型频率显著高于对照组;肠道感染后D-IBS组S/S基因型频率显著高于肠道感染后A-IBS和C-IBS组,L/L基因频率显著低于肠道感染后A-IBS和C-IBS组。VNTRs区:肠道感染后IBS患者sTin2.12/10基因型频率明显高于对照组,各亚型间基因型频率差异无显著性。结论具有L/L基因型的人肠道感染后更易患C-IBS,具有L/S基因型的人肠道感染后更易患D-IBS和A-IBS。肠道感染后C-IBS患者12/12,L/L基因型联合的频率显著高于对照组和肠道感染后A-IBS、D-IBS组,说明12/12,L/L基因型联合可能为肠道感染后C-IBS的危险因素。

Objective To investigate the SERT gene polymorphisms in the IBS after intestinal infections. Methods Study on the SERT gene polymorphisms of VNTRs and 5 - HTrLPR in 100 health people and 231 eases of IBS after intestinal infections by the way of PCR. Results 5 - HTT＇ LPR ： The frequencies of L/L gene was significantly higher in the C - IBS group than in the control group ; The frequencies of S/S gene in the D - IBS group was significantly higher than in the A - IBS and C - IBS groups, but the L/L gene was significantly lower than A - IBS and C- IBS groups. VNTRs： The frequencies of sTin2. 12/10 was significantly higher in the IBS than in the control group. Conclusion L/L gene is the susceptible gene of C - IBS after intestinal infections, IVS gene is the susceptible gene of D -IBS and A- IBS. The frequencies of 12/12 ,L/L gene combine was significantly higher in C -IBS than in the control group and A - IBS,D - IBS groups. It shows that 12/12 ,L/L gene may be a dangers factor to C - IBS after intestinal infections.