类风湿关节炎神经内分泌免疫网络的变化及中医药干预研究进展

Rheumatoid Arthritis Neuroendocrine-Immune Network Changes and Progress in Traditional Chinese Medicine Intervention

类风湿关节炎临床表现多样,发病机制复杂,其病程中综合体现了滑膜增生、炎症、自身免疫、内分泌紊乱等多种病理生理过程,它们相互关联、相互作用,形成了一个错综复杂的网络,单纯从免疫学角度难以阐释RA的发病机制和病变特点,近年来神经内分泌免疫网络途径在RA的发病机制中越来越受到重视,RA病变过程中存在神经内分泌免疫网络的紊乱。中药或中药复方进入机体后能够多靶点、多环节、多层次、多途径发挥作用,对神经内分泌免疫网络能起到很好的良性调节作用。就近年来RA神经内分泌免疫网络的变化及中医药干预作用研究进展做一综述。

The pathogenesis of rheumatoid arthritis is complex, which reflects the course of the integrated synovial hyperplasia, inflammation, autoimmune, endocrine disorders and other pathological physiological processes, they are interrelated and interact, forming an intricate network. Simply from the immunological point is difficult to explain the pathogenesis of RA. In recent years, the features of neuroendocrine-immune （ NEI ） network in the pathogenesis of RA is given more attention. The NEI network disorder is exist in RA. But traditional Chinese medicine can play a very good positive regulatory role of NEI network by multi-target, multi-link, multi-level, multi-channel. The changes of RA NEI network and the intervention of Chinese medicine is reviewed in this paper.