光动力学疗法和声动力学疗法

Photodynamic Therapy and Sonodynamic Therapy

目的:通过对肿瘤治疗中光动力学疗法和声动力学疗法的研究现状及研究进展的综述,以期对临床应用或实验研究起到一定的借鉴作用。方法:本文具体阐述了光动力学疗法和声动力学疗法杀伤肿瘤细胞的分子机制以及光敏剂与声敏剂的分类,介绍了两种方法在肿瘤方面的应用及对新的治疗模式的探索,展望了光动力学疗法和声动力学疗法临床应用的巨大潜力。结果:光动力学疗法和声动力学疗法的研究已取得了一定的成果,但在组织内氧含量、新型光敏剂与声敏剂的开发、药物剂量的把握及对声动力学疗法作用机理的研究方面仍存在问题。结论:光动力学疗法和声动力学疗法作为两种新的肿瘤治疗手段,在肿瘤的防治中已展现出良好的应用前景,但在临床实际应用中光动力学疗法还未普及,而声动力学疗法起步较晚,尚处于研究阶段,未应用于临床。

Objective： This paper summarized the research status and progress ofphotodynamic therapy （PDT） and sonodynamic therapy （SDT）, and we hope this can be a useful reference for clinics or research. Methods： In this review we expound their molecular mechanisms in detail and classi~ the photosensitizer and sonosensitizer, indicate their applications for the cancer treatment and summarize their new treating modes. PDT and SDT have huge potential for cancer treatment. Results： PDT and SDT have achieved a certain results, whereas there are still many problems, such as tissue oxygen content, new photosensitizer and sonosensitizer, drug dosage and mechanisms of SDT. Conclusions： PDT and SDT, which are new methods for treating cancer, have shown a good application prospect. But PDT has not been universal in clinics and SDT is still in the experiment stage.