期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

复方α-酮酸补充的极低蛋白膳食对慢性肾脏疾病患者血压的影响 被引量：3

Effect of very low protein diet supplemented with compound α-ketoacid on blood pressure in chronic kidney disease
原文传递
导出
摘要 目的观察复方α-酮酸补充的极低蛋白膳食(sVLPD)对慢性肾病患者血压的影响。方法53例慢性肾病患者接受标准的低蛋白膳食(LPD,0.6g·kg-1·d-1)3mo后分为2组,对照组28例继续给予LPD,试验组25例给予复方α-酮酸补充的sVLPD(0.3g·kg·d-1),均3mo。比较治疗后2组患者体重、血压、实际蛋白和钠摄入量、血生化指标等。结果治疗6mo后,试验组血压下降(13±s9)/(6±7)mmHg(P<0.05),有7例达到靶血压水平;而对照组血压无明显改变,无一例达到靶值。试验组蛋白摄入量减少(0.25±0.10)g·kg-1·d-1,钠减少(35±6)mmol·d-1,对照组没有蛋白摄入和钠摄入的改变,2组差异显著(P<0.05)。2组患者体重、血清清蛋白、血红蛋白浓度在治疗前后均无显著变化。结论复方α-酮酸补充的sVLPD有益于慢性肾病患者的降压治疗,且不影响患者的营养状态,这可能与盐摄入的减少和复方α-酮酸的补充有关。
作者 刘进 钟华
机构地区 泸州医学院附属医院肾内科 四川大学华西医院
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2010年第1期70-72,共3页 Chinese Journal of New Drugs and Clinical Remedies
关键词 肾疾病 慢性病 高血压 膳食 限制蛋白 酮酸类 复方Α-酮酸 kidney diseases chronic diseases hypertension diet protein-restricted keto acids compound α-ketoacid
分类号 R977.4 [医药卫生—药品]
  • 相关文献

参考文献8

  • 1BRUNORI G, VIOLA BF, PARRINELLO G, et al. Efficacy and safety of a very-low-protein diet when postponing dialysis in the elderly: a prospective randomized multicenter controlled study[J].Am J Kidney Dis, 2007, 49(5) : 569-580.
  • 2GATES PE, TANAKA H, HIATT WR, et al. Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension[J]. Hypertension, 2004, 44(1) : 35-41.
  • 3di IORIO BR, MINUTOLO R, de NICOLA L, et al. Supplemented very low protein diet ameliorates responsiveness to erythropoietin in chronic renal failure[J]. Kidney Int, 2003, 64 (5): 1822-1828.
  • 4BELLIZZI V, di IORIO BR, de NICOLA L, et al. Very low protein diet supplemented with ketoanalogs improves blood pressure control in chronic kidney disease[J]. Kidney Int, 2007, 71(3): 245-251.
  • 5APPEL LJ, BRANDS MW, DANIELS SR, et al. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association[J]. Hypertension, 2006, 47(2) : 296-308.
  • 6CIANCIARUSO B, BELLIZZI V, MINUTOLO R, et al. Renal adaptation to dietary sodium restriction in moderate renal failure resulting from chronic glomerular disease[J]. J Am Soc Nephrol, 1996,7(2) : 306-313.
  • 7de NICOLA L, MINUTOLO R, BELLIZZI V, et al. Achievement of target blood pressure levels in chronic kidney disease: a salty question?[J]. Am J Kidney Dis, 2004, 43 (5): 782-795.
  • 8彭红英,王玉,李晓玫.饮食限盐对非透析慢性肾脏病患者血压影响的研究[J].中国实用内科杂志,2008,28(4):280-282. 被引量：8

二级参考文献7

  • 1Weir MR,Fink JC. Salt intake and progression of chronic kidney disease:an overlooked modifiable exposure? A commentary [ J ]. Am J Kidney Dis,2005,45( 1 ) :176 - 188
  • 2Cianciaruso B ,Bellizzi V,Minutolo R,et al. Renal adaptation to dietary sodium restriction in moderate renal failure resulting from chronic glomerular disease[J]. J Am Soc Nephrol ,1996,7 :306 -313.
  • 3Johnson R J, Herrera-Acosta J, Schreiner GF,et al. Subtle acquired renal injury as a mechanism of salt-sensitive hypertension [ J ]. N Engl J Med,2002,346(12) :913 -923.
  • 4Singer DR,Markandu ND,Sugden AL, et al. Sodium restriction in hypertensive patients treated with a converting enzyme inhibitor and a thiazide[ J ]. Hypertension, 1991,17:798 - 803.
  • 5Imanishi M,Yoshioka K,Okumura M,et al. Sodium sensitivity related to albuminuria appearing before hypertension in type 2 diabetic patients [ J ]. Diabetes Care,2001,24 ( 1 ) : 111 - 116.
  • 6du Cailar G, Ribstein J, Mimran A. Dietary sodium and target organ damage in essential hypertension [ J ]. Am J Hypertens,2002, 15 ( 3 ) :222 - 229.
  • 7Heeg JE,de Jong PE, van der Herin GK,et al. Efficacy and variability of the antiproteinuric effect of ACE inhibition by lisinopril [J]. Kidney Int,1989,36(2) :272 -279.

共引文献7

同被引文献44

  • 1李松杨,赵学智,刘亚玲.尿毒症患者偶测血压与动态血压的对比研究[J].中国血液净化,2004,3(7):377-379. 被引量：6
  • 2刘必成.延缓慢性肾脏病进展的现代策略[J].继续医学教育,2006,20(5):57-67. 被引量：7
  • 3李健芝,庾江东,何平平,吴艳平,张平,彭佑铭.终末期肾脏疾病患者透析治疗的相关因素分析[J].中国组织工程研究与临床康复,2007,11(12):2341-2344. 被引量：8
  • 4National kidney Foundation-K/DOQI. Clinical practice guidelines for chronic kidney disease, evaluation, classification and stratification [J]. AMJ Kidney Dis, 2002, 39 (suppl1) :s1-s266.
  • 5Beliizzi V, Di Iorio BR, De Nicola L, et al. Very low protein diet supplemented with Ketoanalogs improves blood pressure contral in chronic kidney disease [J]. Kidney Int, 2007, 71 (3): 245-251.
  • 6lkizler TA.CKD classification: time to move beyond KDOQI [J]. J Am Soc Nephrol, 2009, 20 (5) : 929-930.
  • 7Cupisti A, Aparicio M, Barsotti G. Potential benefits of renal diets on cardiovascular risk factors in chronic kidney disease patients [J]. Renal Fail, 2007, 29 (5) : 529-534.
  • 8Appel L J, Brands MW, Daniels SR, et al. Dietaryapproaches to prevent and treat hypertension: a scientific statement from the American Heart Association[J]. Hypertension, 2006, 47 (2): 296-308.
  • 9Vassalotti JA, Uribarri J, Chen SC, et al. Trends in mineral metabolism: kidney early evaluation program (KEEP) and the national health and nutrition examination survey (NHANES) 1999-2004[J]. Am J Kidney Dis, 2008, 51 (4 Suppl 2): S56-S68.
  • 10Levin A, Bakris GL, Molitch M, et al. Prevalence of abnormal serum vitamin D, PTH, calciumand phosphorus in patients with chronic kidney disease: results of study to evaluate early kidney disease [J]. Kidney Int, 2007, 71 (1): 31-38.

引证文献3

二级引证文献11

中国新药与临床杂志
2010年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部