期刊文献+

一种新的内皮素受体拮抗剂——clazosentan 被引量:1

Clazosentan:A new endothelin receptor antagonist
下载PDF
导出
摘要 脑血管痉挛(cerebral vasospasm,CVS)是动脉瘤性蛛网膜下腔出血(subarachnoid hemorrhage,SAH)后的常见并发症,是致死和致残的主要原因。clazosentan为一种特异性的A型内皮素受体竞争性拮抗剂,动物实验和临床试验都证实该药可缓解SAH引发的CVS,本文综述clazosentan的研究进展。 Cerebral vasospasm(CVS) is a common complication following aneurysmal subarachnoid hemorrhage(SAH),and is a leading cause of death and disability in SAH patients.Clazosentan,a synthetic endothelin(ET) A receptor(ETA) antagonist,has been proved to be effective for SAH-induced CVS in animal experiments and clinical trials.
作者 陈罡 史继新
出处 《医学研究生学报》 CAS 2010年第3期301-304,共4页 Journal of Medical Postgraduates
基金 国家自然科学基金(30700866)
关键词 clazosentan 蛛网膜下腔出血 脑血管痉挛 Clazosentan Subarachnoid hemorrhage Vasospasm
  • 相关文献

参考文献24

  • 1Ingall T, Asplund K, Mahonen M, et al. A multinational comparison of subarachnoid hemorrhage epidemiology in the WHO MONICA stroke study [J]. Stroke, 2000, 31(5) :1054-1061.
  • 2Ingall TJ, Whisnant JP. Epidemiology of subarachnoid hemorrhage. //Yanagihara T, Piepgras DG, Atkinson JLD, editors, Subarachnoid hemorrhage. Medical and Surgical Management [ M]. New York: Marcel Dekker, 1998 : 63-78.
  • 3Kassell NF, Torner JC, Haley EC Jr, et al. The international cooperative study on the timing of aneurysm surgery. Part 1 : Overall management results [ J]. J Neurosurg, 1990, 73 ( 1 ) : 18-36.
  • 4Roux S, Breu V, Giller T, et al. Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm [ J ]. J Pharmacol Exp Ther, 1997, 283(3) :1110-1118.
  • 5Macdonald RL, Kassell NF, Mayer S, et al. Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, doubleblind, placebo-controlled phase 2 dose-finding trial [J]. Stroke, 2008, 39( 11 ) :3015-3021.
  • 6Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial ceils [J]. Nature, 1988, 332(6163) :411-445.
  • 7Dammanahalli KJ, Sun Z. Endothelins and NADPH oxidases in the cardiovascular system [ J ]. Clin Exp Pharmacol Physiol, 2008, 35( 1 ) :2-6.
  • 8肖继明,徐军,陈锐华.冠心病患者血浆内皮素水平与心脏收缩功能的研究[J].医学研究生学报,2008,21(11):1175-1177. 被引量:9
  • 9Makita T, Sucov HM, Gariepy CE, et al. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons [J]. Nature, 2008, 452(7188) :759-763.
  • 10Zimmermann M, Seifert V. Endothelin and subarachnoid hemorrhage : an overview [ J]. Neurosurgery, 1998, 43 (4) :863-875.

二级参考文献63

共引文献45

同被引文献2

引证文献1

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部