作用于过氧化物酶体增殖物激活受体的中药活性成分研究

Active components in Chinese medicine that act on peroxisome proliferator activated receptors

过氧化物酶体增殖物激活受体(peroxisome proliferator activated receptor,PPAR)是一类由配体激活的核转录因子,属于核内受体超家族成员。PPAR存在天然配体和人工合成配体2类。天然配体主要来源于食物和机体的代谢产物,人工合成配体主要是贝特类降脂药物和噻唑烷二酮类降糖药物。目前发现,有些中药成分也可以作为PPAR的配体。文中对可作用于PPAR的中药配体研究作一综述。

Peroxisome proliferator activated receptors（PPARs） are ligand-activated transcription factors,as well as a group of nuclear receptor isoforms.PPARs can be either natural ligands or synthetic ligands.Natural ligands mainly come from food and body metabolites.Synthetic ligands are mainly the beit drugs for lipid reduction and the thiazolidinedione drugs for glucose reduction.Currently,several Chinese herbal medicines have exhibited considerable PPAR ligand-binding activity.