肝炎肝硬化患者血清载脂蛋白AI和载脂蛋白B检测的临床意义

Clinical Significance of aPoA-I and aPoB Determination in Patients with Posthepatitic Cirrhosis

目的探讨肝硬化患者血清中载脂蛋白A-I(aPoA-I)和载脂蛋白B(aPoB)与肝炎肝硬化的关系及临床意义。方法对2006年4月—2009年6月于清苑县人民医院就诊的52例患者和26例健康体检者同时测定血清中aPoA-I和aPoB的水平,并进行比较。结果肝硬化代偿组、失代偿组血清中aPoA-I和aPoB均明显低于对照组,差异有统计学意义(均P<0.01)。肝硬化Child-pugh分级级别越高,血清中aPoA-I和aPoB下降水平越明显。结论血清中aPoA-I和aPoB的水平降低与肝硬化及肝硬化Child-pugh分级关系密切。对判断肝硬化患者病情及预后有重要参考意义。

[Objective]To investigate the relationship between serum aPoA-I and aPoB and posthepatitic cirrhosis.[Methods]A total of 52 patients and 26 healthy people in Qingyuan County People＇s Hospital were detected for serum aPoA-I and apoB from April 2006 to January 2009.The results were compared.[Results]There was a significant decrease of serum ApoA-I and aPoB in the control group,compensatory cirrhosis group and the broken compensatory group in turn.The differences between the 3 groups were significant （P〈0.01）.With the Child-pugh grade increased,the level of serum aPoA-I and aPoB decreased significantly.[Conclusion]The decrease of serum aPoA-I and aPoB closely relates with liver posthepatitic cirrhosis and Chi1d-pugh classification,which has significant value in identification of the pathogenesis and prognosis of posthepatitic cirrhosis.