pH响应性聚膦腈水凝胶的制备与表征

Preparation and Characterization of pH-Sensitive Polyorganophosphazene Hydrogel

以N,N-二甲基乙二胺为阳离子型取代基,甲基丙烯酸羟乙酯或烯丙胺为共取代基,制备了同时带有pH响应性侧基和不饱和双键侧基的聚膦腈.该聚合物的结构和组成经1H NMR和FTIR确认后,通过自由基引发交联得到聚膦腈凝胶.凝胶在不同介质中的吸水率测试结果表明,该阳离子型聚膦腈水凝胶的溶胀行为受聚合物侧基组成、介质pH、离子强度和阴离子价态影响显著,有望与葡萄糖氧化酶结合后实现对胰岛素的葡萄糖响应释放.

Using N,N-dimethyl-ethylenediamine as cationic substitute and 2-hydroxyethyl methacrylate or allylamine as co-substitute,a kind of pH-sensitive polyorganophosphazenes bearing unsaturated side group was prepared.Their compositions and structures were confirmed by 1H NMR and FTIR analysis.Polyphosphazene gels could be obtained by radical crosslinking the polymers.These gels exhibited different water absorption behavior significantly depending on chemical composition,environmental pH,ion strength and ionic charge.The results revealed the pH-sensitive polyorganophosphazene hydrogels could be good candidates for the study of glucose-mediated insulin release in combination with glucose oxidase.