醋酸去氨加压素联合膀胱训练治疗儿童原发性遗尿症的疗效

Curative Effect of Desmopressin Acetate Combined with Bladder Training Therapy on Primary Nocturnal Enuresis in Children

目的观察醋酸去氨加压素(DDAVP)联合膀胱训练治疗儿童原发性遗尿症(PNE)的疗效及复发率。方法采用前瞻性实验研究方法,将2007年1月-2008年12月在本院儿科遗尿专科门诊就诊的100例PNE患儿随机分为对照组和观察组,每组各50例。对照组单纯应用DDAVP口服治疗;观察组在应用DDAVP口服治疗的同时进行膀胱训练,疗程均为3个月。疗程结束比较2组疗效。疗程结束随访3个月,比较2组远期、近期复发率。应用SPSS 13.0软件进行统计学分析。结果对照组总有效率为72.9%,近期复发率为22.9%,远期复发率为54.3%;观察组总有效率为91.3%,近期复发率为11.9%,远期复发率为28.6%。观察组总有效率显著高于对照组(Z=-1.972,P=0.049),2组近期复发率比较差异无统计学意义(χ2=1.632,P=0.201),观察组远期复发率显著低于对照组(χ2=5.249,P=0.022)。结论DDAVP联合膀胱训练治疗PNE疗效显著,且能降低远期复发率。

Objective To observe the curative effect and recurrence rate of desmopressin acetate （DDAVP） combined with bladder training therapy on primary nocturnal enuresis（PNE） in chlidren. Methods One hundred children with PNE were randomly divided into control group and observation group （50 cases in each group）. Children in control group were treated with simple DDAVP, and patients in observation group were treated with bladder training while DDAVP was using. The course of treatment were 3 months. The therapeutic effect between the 2 groups when the treatment was finished was compared and then followed up all the cases for 3 months to compare the near - term and long - term recurrence rate between the 2 groups. SPSS 13.0 software was used to analyze the data. Results The total effective rate in control group was 72.9% ,and the near - term recurrence rate and the long - term recurrence rate were 22.9% and 54.3% , respectively. The total effective rate in observation group was 91.3% , and the near - term recurrence rate and the long - term recurrence rate were 11.9% and 28.6% ,respectively. The total effective rate was significantly higher in observation group than that in control group （Z = -1. 972, P = 0. 049）. The near - term recurrence rate in 2 groups had no significant difference（x^2 = 1. 632, P = 0.201 ）. The long - term recurrence rate was extremely lower in observation group than that in control group（x^2 = 5. 249,P = 0. 022）. Conclusions There is significant curative effect that DDAVP combined with bladder training therapy on PNE in children,and it can lower the long -term recurrence rate.