桦褐孔菌多糖口服液澄清工艺研究

Optimization of inonotus obliquus polysaccharide oral solution

优选ZTC1+1Ⅲ型澄清剂用于桦褐孔菌多糖口服液的澄清工艺。在单因素试验基础上,选择ZTC1+1Ⅲ型澄清剂用量、澄清温度、保温时间为自变量,吸光度为响应值,利用Box-Benhnken中心组合试验和响应面分析法,模拟得到二次多项式回归方程的预测模型。优化最佳澄清工艺参数为:ZTC1+1Ⅲ型用量(B/A)7.409%/3.71%,澄清温度(B/A)为73.63℃/53.63℃,保温时间为20.047min。ZTC1+1Ⅲ型澄清剂的澄清工艺可用于桦褐孔菌多糖口服液的除杂。

To determine the optimum process with ZTC1＋1Ⅲ clarifier for inonotus obliquus polysaccharide oral solution. On the basis of single-factor test,the mathematical regression model is established a bout the dependent variable （absorption） and independent variables （the amount of ZTC1＋1Ⅲ, Clarifying teamperature, holding time） through Box-Benhnken center composite design and response surface methodology. The optimum extraction conditions as follows： the amount of ZTC1＋1Ⅲ （B/A） 7. 409 %/3. 71 %, Clarifying teamperature（B/A）73. 63/53. 63 ℃, holding time 20. 047 rain. Removing im purity with ZTC1＋1Ⅲ elarifierean he used for inonotus obliquus polysaccharide oral solution.