摘要
A型激酶锚定蛋白12（AKAP12）是一种细胞支架蛋白，能够锚定一些关键信号分子，如蛋白激酶A（PKA）、蛋白激酶C（PKC）和细胞周期素D1（eyelin D1），以及动态调节β2-肾上腺素受体复合物。AKAP12在多条信号转导通路中发挥重要作用。研究发现，AKAP12在前列腺癌、食管癌、胃癌等多种肿瘤中表达下凋或缺失，是一个肿瘤抑制基因，同时也是潜在的肿瘤转移抑制基因。
A-kinase anchoring protein 12 （AKAP12） ,is a kind of cell scaffold proteins, and can organize the complex of protein kinase A（PKA） and PKC as well as other signal molecules such as cyclin D1, and it is an important regulator of the β2-adrenergic receptor complex, which demonstrates the participation of AKAP12 in diverse signal transduction pathways. AKAP12 contains deletions or downregulation in variours tumors, including prostate cancers, gastric carcinomas and esophagus cancer, suggesting that the inactivation of AKAP12 expression may be linked to oncogenesis. AKAP12 is also a potential suppressor gene in metastasis of cancers.
出处
《国际肿瘤学杂志》
CAS
2010年第1期9-11,共3页
Journal of International Oncology
