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A型激酶锚定蛋白12与肿瘤

A-kinase anchoring protein 12 and tumors
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摘要 A型激酶锚定蛋白12(AKAP12)是一种细胞支架蛋白,能够锚定一些关键信号分子,如蛋白激酶A(PKA)、蛋白激酶C(PKC)和细胞周期素D1(eyelin D1),以及动态调节β2-肾上腺素受体复合物。AKAP12在多条信号转导通路中发挥重要作用。研究发现,AKAP12在前列腺癌、食管癌、胃癌等多种肿瘤中表达下凋或缺失,是一个肿瘤抑制基因,同时也是潜在的肿瘤转移抑制基因。 A-kinase anchoring protein 12 (AKAP12) ,is a kind of cell scaffold proteins, and can organize the complex of protein kinase A(PKA) and PKC as well as other signal molecules such as cyclin D1, and it is an important regulator of the β2-adrenergic receptor complex, which demonstrates the participation of AKAP12 in diverse signal transduction pathways. AKAP12 contains deletions or downregulation in variours tumors, including prostate cancers, gastric carcinomas and esophagus cancer, suggesting that the inactivation of AKAP12 expression may be linked to oncogenesis. AKAP12 is also a potential suppressor gene in metastasis of cancers.
出处 《国际肿瘤学杂志》 CAS 2010年第1期9-11,共3页 Journal of International Oncology
关键词 肿瘤 A型激酶锚定蛋白质类 Neoplasms A kiuase anchor proteins
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参考文献18

  • 1Gordon T, Grove B, Lofius JC, et al. Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by nayastbenia gravis sera. J Clin invest, 1992, 90(3) :992-999.
  • 2Colledge M, Scott JD. AKAPs:from structure to function. Trends Cell Biol, 1999, 9(6) :216-221.
  • 3Gelman IH. The role of SSeCKS/gravin/AKAP12 scaffolding proteins in the spaeiotemporal control of signaling pathways in oncogenesis and development. Front Biosei, 2002, 7 :d1782-1797.
  • 4Jin Z, Hamilton JP, Yang J, el al. Hypermethylation of the AKAPI2 promoter is a biomarker of Barrett' s-associated esophageal neoplastic progression. Cancer Epidemiol Biomarkers Prey, 2008, 17 ( 1 ) : 111- 117.
  • 5Choi MC, Jong HS, Kim TY, et al. AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity. Oncogene, 2004 23 (42) :7095-7103.
  • 6Tessema M, Willink R, Do K, et al. Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. Cancer Res, 2008, 68 (6) : 1707-1714.
  • 7Yildirim M, Paydas S, Tanriverdi K, et al. Gravin gene expression in acute leukaemias: clinical importance and review of the literature. Leuk Lymphoma, 2007, 48 ( 6 ) : 1167-1172.
  • 8Flotho C, Paulun A, Batz C, et al. AKAP12, a gene with tumour suppressor properties, is a target of promoter DNA methylation in childhood myeloid malignancies. Br J Haematol, 2007, 138(5) :644- 650.
  • 9关明,徐翀,刘维薇,陈波斌.儿童急性淋巴细胞白血病患者肝癌缺失基因1启动子的异常甲基化[J].中华检验医学杂志,2008,31(4):389-393. 被引量:4
  • 10Liu H, Huang X, Wang H, et al. Dexamethasone inhibits proliferation and stimulates SSeCKS expression in C6 rat glioma cell line. Brain Res, 2009, 1265 : 1-12.

二级参考文献15

  • 1武立鹏,朱卫国.DNA甲基化的生物学应用及检测方法进展[J].中华检验医学杂志,2004,27(7):468-474. 被引量:25
  • 2张晓丹,武海萍,周国华.焦测序技术及其在遗传分析中的应用[J].分析化学,2006,34(4):582-586. 被引量:19
  • 3Yuan BZ, Miller M J, Keck CL, et al. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer ( DLC-1 ) homologous to rat RhoGAP. Cancer Res, 1998,58:2196-2199.
  • 4Yuan BZ, Durkin ME, Popescu NC. Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancels. Cancer C, enet Cytogenet, 2003,140:113-117.
  • 5Kim TY, Jong HS, Song SH, et al. Transcriptional silencing of the DLC-ltumor suppressor gene by epigenetic mechanism in gastric cancer cells. Oncogene, 2003,22:3943-3951.
  • 6Dammann R, Strunnikova M, Schagdarsurengin U, et al. CpG island methylation and expression of tumour-associated genes in lung carcinoma. Eur J Cancer, 2005,41:1223-1236.
  • 7Pang JC, Chang Q, Chung YF, et al. Epigenetic inactivation of DLC-lin supratentorial primitive neuroectodermal tumor. Hum Pathol, 2005,36:36-43.
  • 8Wong CM, Lee JM, Ching YP, et al. Genetic and epigenetic alterations of DLC-lgene in hepatecellular carcinoma. Cancer Res, 2003,63:7646-7651.
  • 9Gomez del Pulgar T, Benitah SA,Valeron PF, et al. Ptho GTPaae expression in tumourigenesis: evidence for a significant link. Bioessays, 2005,27:602-613.
  • 10Guan M, Zhou X, Soulitzis N, et al. Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications. Clin Cancer Res ,2006 ,12 :1412-1419.

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