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转化生长因子-β1与肺癌的关系 被引量：2

Relationship between transforming growth factor β1 and lung cancer
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摘要 转化生长因子-β1（TGF-β1）是细胞因子超家族的成员之一，近年研究发现，TGF-β1及其受体的异常与肺癌的发生、发展及预后存在密切关系。TGF-β1的检测对肺癌的早期诊断、分期、治疗效果及预后评估均有重要作用。 Transforming growth factor β1 （ TGF-β1 ） is a member of cytokine superfamily. Recent studies reveal that the abnormality of TGF-β1 and its receptors is strongly related to genesis, progression and prognosis of lung cancer. It plays an important role in early diagnosis, stage and assessment of treatment and prognosis of lung cancer.
作者 张柳(综述) 陈建荣(审校) 蔡映云(审校)
机构地区 南通大学第二附属医院呼吸科
出处 《国际肿瘤学杂志》 CAS 2010年第1期46-49,共4页 Journal of International Oncology
基金 江苏省“六大人才高峰”资助课题（06-B-18）,南通市科委社会发展计划项目（S2006048）
关键词 肺肿瘤 转化生长因子-Β1 早期诊断 Lung neoplasms Transforming growth factor beta Early diagnosis
分类号 R575.2 [医药卫生—消化系统]
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参考文献15

  • 1Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin, 2009, 59(4) :225-249.
  • 2Fong YC, Hsu SF, Wu CL, et al. Transforming growth factor-betal increases cell migration and betal integrin up-regulation in human lung cancer cells. Lung Cancer, 2009, 64( 1 ) :13-21.
  • 3Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol, 2009, 19(8) :385-394.
  • 4Gordon KJ, Blobe GC. Role of transforming growth factor-beta superfamily signaling pathways in human disease. Biochim Biophys Acta, 2008, 1782(4) :197-228.
  • 5Cohen P, Nunn SE, Peehl DM. Transforming growth factor-beta induces growth inhibition and IGF-binding protein-3 production in prostatic stromal cells:abnormalities in cells cultured from benign prostatic hyperplasia tissues. J Endocrinol, 2000, 164(2) :215-223.
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  • 8Liu Z, Kobayashi K, Dinther M, et al. VEGF and inhibitors of TGF {beta} type-I receptor kinase synergistically promote blood-vessel formation by inducing {alpha} 5-integrin expression. J Cell Sci, 2009, 122( pt 18) :3294-3302.
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国际肿瘤学杂志
2010年 第1期

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