期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Ran调节因子RanBP1的生物学作用 被引量：4

Biology roles of Ran's regulator RanBP1
下载PDF
导出
摘要 RanBP1位于细胞质中,是Ran的结合蛋白,它能够抑制RCC1的活性,间接地刺激了RanGTPase活性,促进GTP的水解。RanBP1在细胞的核质运输、纺锤体的组装、细胞周期、有丝分裂控制和有丝分裂结束后的核重组中都有一定的调节作用。 RanBP1, which locates in cytoplasm, is the binding protein of Ran. RanBP1, which restrains the activity of RCC1, can indirectly increase the activity of RanGTPase, and promote the hydrolization of GTP. It plays roles in regulating the nucleocytoplasmic transport, the spindle assembly, cell cycle, the mitotic control, and the nuclear reconstitution after the end of carring on mitosis.
作者 曾晓 孙露霜 杨立琳 曹允考
机构地区 东北农业大学动物医学学院
出处 《东北农业大学学报》 CAS CSCD 北大核心 2010年第3期150-153,共4页 Journal of Northeast Agricultural University
基金 东北农业大学博士启动基金
关键词 RanBP1 RAN 细胞周期 有丝分裂 RanBP1 Ran cell cycle mitosis
分类号 Q78 [生物学—分子生物学] Q503 [生物学—生物化学]
  • 相关文献

参考文献11

  • 1曹允考,张贵学,陈大元,孙青原.GTPase Ran及其生物学作用[J].细胞生物学杂志,2004,26(3):241-246. 被引量：9
  • 2Bressan A, Somma M P, Lewis J, et al. Characterisation of the opposite-strand genes from the mouse bidirectionally transcribed Htf9 locus[J]. Gene, 1991, 103: 201-209.
  • 3Bischoff F R, Krebber H, Smirnova E, et al. Co-activation of Ran- GTPase and inhibition of GTP dissociation by RanGTP binding protein RanBPI[J]. EMBO J, 1995, 1: 705-715.
  • 4Di Matteo G, Salerno M, Guarguaglini G, et al. Interactions with single-stranded and double-stranded DNA-binding factors and alternative promoter conformation upon transcriptional activation of the HtJg-a/RanBP1 and HtJg-c genes[J]. J Biol Chem, 1998, 273: 495-505.
  • 5Guarguaglini G, Renzi L, Ottavio F, et al. Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo[J]. Cell Growth Differ, 2000, 11 : 455-465.
  • 6Di Fiore B, Guarguaglini G, Palena A, et al. Two E2F-binding sites independently control growth-regulated and cell-cycle regulated transcription of the Htfg-a/RanBPl gene[J]. J Biol Chem,1999, 274: 10339-10348.
  • 7Plafker K, Macara I G. Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBPI[J]. Mol Cell Biol, 2000, 20: 3510- 3521.
  • 8Di Fiore B, Ciciarello I, Iangiacasale R, et al. Mammalian RanBP1 regulates centrosome cohesion during mitosis[J]. J Cell Sci, 2003,116:3399-3411.
  • 9Tedeschi A, Ciciarello M, Manqizcasale R, et al. RanBP1 localizes a subset of mitotic regulatory factor on spindle microtubules and regulates chromosome segregation in human cells[J]. J Cell Sci, 2007, 120: 3748-3761.
  • 10Rensen W M, Roscioli E, Tedeschi A, et al. RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner[J]. Oncogene, 2009, 10: 1038-1039.

二级参考文献32

  • 1WILDE A, ZHENG Y. Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran [J]. Science, 1999, 2.84(5418): 1359 - 1362.
  • 2HETZER M, GRUSS O J, MATI'AJ I W. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly [J]. Nat Cell Biol, 2002, 4(7):E177 - 184.
  • 3NAKAMURA M, MASUDA H, HORI1 J, et al. When overexpressed, a novel centrosomal protein, RanBPM,causes ectopic microtubule nucleation similar to gamma-tubulin [J]. J Cell Biol, 1998, 143(4): 1041 - 1052.
  • 4VERMOS I, RAATS J, HIRANO T, etal. Xklpl, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning [J]. Cell, 1995, 81(1): 117 - 127.
  • 5KAHANA J A, CLEVELAND D W. Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly[J]. J Cell Biol, 1999, 146(6): 1205- 1210.
  • 6AITCHISON J D, ROUT M P. A tense time for the nuclear envelope [J]. Cell, 2002, 108(3): 301 - 304.
  • 7ZHANG C, CLARK P R. Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts [J]. Science, 2000, 288(5470): 1429 - 1432.
  • 8RYAN K J, MCCAFFERY J M, et al. The Ran GTPase cycle is required for yeast nuclear pore complex assembly [J]. J Cell Biol, 2003, 160(7): 1041 - 1053.
  • 9WALTHER T C, ASKJAER P, et al. RanGTP mediates nuclear pore complex assembly [J]. Nature, 2003, 424(6949):689 - 694.
  • 10RIBBECK K, LIPOWSKY G, KENT H M, et al. NTF2 mediates nuclear import of Ran [J]. EMBO J, 1998, 17(22):6587 - 6598.

共引文献8

同被引文献15

引证文献4

二级引证文献3

东北农业大学学报
2010年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部