白花前胡提取物对慢性阻塞性肺疾病继发性肺动脉高压的影响

Effects of Extract from Baihua Qianhu on Pulmonary Hypertension in Patients with Chronic Obstractive Pulmonary EmphysemaGH

目的：评价中药白花前胡提取物（ＱＦ－８）降低慢性缺氧性肺动脉高压的急性疗效。方法：采用右心漂浮导管检测法观察口服ＱＦ－８对１１例慢性阻塞性肺疾病继发性肺动脉高压患者血流动力学和血气等的影响。结果：服药后３０ｍｉｎ时，肺动脉平均压、肺总阻力和肺血管阻力均明显下降，６０ｍｉｎ时分别下降１４％、２３％和３１％（Ｐ均＜０．０１），动脉血氧分压未见下降，氧运输量增加（Ｐ＜０．０５），体动脉压和体循环阻力等无变化。结论：ＱＦ－８有较好的选择性扩张肺血管、降低缺氧性肺动脉高压作用。

This paper was to evaluate the acute effects of QF 8 (the extract of baihua qianhu, a chinese traditional medicine) on lowering hypoxic pulmonary hypertension. Methods:Eleven patients with pulmonary hypertension secondary to COPD underwent right heart catheterization. The indexes of hemodynamics and arterial blood gases were measured before and after oral administration of QF 8. ,and pulmonary vascularresistance (PVR) weresignificantlydecreased in30minutesaftertaking QF 8. The decreased percentage of mPAP, TPVR, and PVR in 60 minutes after taking QF 8 was 14% 23% and31%respectively(all P<0.01).QF 8alsoincreasedoxygentransport (P<0.05), but it exerted no effect on other parameters of hemodynamics and arterial blood gases in patients.