多梗塞性痴呆及Alzheimer病患者血清中载脂蛋白含量变化的研究

A STUDY OF CHANGES OF APOLIPOPROTEIN IN SERUM OF PATIENTS WITH MULTI-INFARCT DEMENTIA AND ALZHEIMER'S DISEASE

目的：探讨血清中载脂蛋白含量变化在多梗塞性痴呆（MID）及Alzhimer病（AD）发病中所起的作用。方法：用圆周免疫扩散法测定MID25例、AD25例及对照组25例的血清载脂蛋白A1（apoA1）、载脂蛋白B100（apoB100）及载脂蛋白E（apoE）含量，同时用全自动生化分析仪测定每组患者血清胆固醇（TC）及甘油三脂（TG）含量，并作对比分析。结果：MID患者血清apoA1明显降低，apoB100明显升高，而血清中TC、TG及apoE在三组间差异无显著性。结论：MID患者血中apoA1、apoB100的异常改变可加速动脉硬化，可能是MID发病的重要危险因素之一。

Objective: To study the effects of the changs of apoipoprotein in serum on multi -infarct dementia (MID) and Alzheimer's disease (AD). Methods: Radioimmunoassay was carried out to observe the changes of apolipoprotein A1 (apoA1), apolipoprotein B100 (apoB100) and apoipoprotein E(apoE) in serum of 25 patients with MID, 25 patients with AD and 25 controls. The concentrations of cholesterol(TC) and triglyceride (TG) in serum were assayed for the three groups by the automatic biochemistry analysor. Results: Serum apoA1 concentration was decreased and apoB100 concentration was increased significantly in MID as compared with controls. The concentrations of TC, TG and apoE in serum had no significan changes between the three groups. Conclusions: The changes of apoA1 and apoB100 may accelerate arteriosclerosis and thus become one of the important risk factors for MID.