西酞普兰与氯米帕明治疗强迫症的对照观察

A comparative study of Citalopram and clomipramine in the treatment of obsessive-compulsive disorder

目的比较西酞普兰与氯米帕明治疗强迫症的疗效和副反应。方法把60例强迫症患者随机分成两组，分别给予西酞普兰及和氯米帕明治疗，疗程8周，应用Yale—Brown强迫症量表（Y—BOCS）、汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量袁（HAMA）评定疗效，用副反应量表（TESS）评定治疗过程中的不良反应。结果治疗后西酞普兰组与氯米帕明组的Y—BOCS、HAMD．HAMA评分均显著下降（p〈0．01），两组间疗效比较无显著差异（p〉0．05）。氯米帕明组出现不良反应共18例，西酞普兰组8例，两组间具有显著差异（p〈0．01），主要差别表现在嗜睡、口干便秘和乏力等方面。结论西酞普兰治疗强迫症疗效与氯米帕明相当，副反应小，安全性高。

Objective To study the efficacy and side effects of citalopram and clomipramine in the treatment of obsessive-compulsive disorder. Method 60 patients with obsessive-compulsive disorder were randomly assigned into citalopram group and clomipramine group for eight weeks, The efficacy was assessed with Yal-Brown obsessive-compulsive scale （Y-BOCS） , Hamilton depression scale （HAMD） ~ and Hamilton anxiety scale （HAMA）, noted the side effect at the same time. Results： The scores of Y-BOCS HAMD, HAMA reduced significantly after treatment in both groups （P〈0.01 ）, No significant difference was found in the efficacy between citalopram group and clomipramine group （p〉0.05） . But the side effect of citalopram group was less significantly than clomipramine group in somnolence, hypodynamic, thirst and constipation （p〈0.05or0.01） . Conclusion： Citalopram was an effective drug in the treatment of obsessive-compulsive disorder like clomipramine, the side effect of citalopram was less than clomipramine.