阿托伐他汀钙治疗脑梗死患者颈动脉粥样硬化斑块的临床研究

Clinical Research on the Atorvastatin Calcium in the Treatment of Cerebral Infarction Patients with Carotid Atherosclerosis Plaque

目的观察阿托伐他汀钙对脑梗死患者颈动脉粥样硬化斑块的治疗作用。方法脑梗死患者随机分为研究组（40例）和对照组（38例），研究组阿托伐他汀钙20mg／晚，阿司匹林100mg／日，对照组阿司匹林100mg／日，饮食控制或服用非他汀类降脂药，分别于入院时，治疗3个月、6个月、12个月动态监测患者的血脂水平，并进行颈动脉超声检查，评估颈动脉粥样硬化斑块积分。结果研究组3个月、6个月、12个月血清TC、LDL—C均比治疗前有明显降低（P〈0．01），HDL—c治疗12个月后有明显升高（P〈0．01）。对照组血清TC、TG、LDL—C均比治疗前稍增高，血清HDL—C与治疗前无明显变化。研究组治疗6个月、12个月颈动脉斑块积分降低，对照组治疗6个月、12个月颈动脉斑块积分增大（P〈0．05）。结论阿托伐他汀钙降脂效果良好，有减少、稳定颈动脉斑块效果。可改善脑梗死患者颈动脉硬化程度，减少缺血性卒中的复发。

Objective To observe the effect of Atorvastatin Calcium in the treatment of cerebral infarction patients with carotid atherosclerosis plaque. Method The cerebral infarction patients were at random divided into research group of 40 cases and control group of 38 cases. The Atorvastatin Calcium of 20 mg each night and Aspirin of 100 mg each day were used in the research group, while the Aspirin of 100 mg each day and diet control or taking the non-statin lipid-lowering drugs were carried out in the control group. The examination of blood fat level and the carotid artery ultrasound check were respectively conducted on hospitalization or after 3 months, 6 months or 12 months＇ treatment, then appraising the accumulative marks of carotid atherosclerosis plaque. Result The values of TC and LDL-C in serum after the 3-month, 6-month or 12 month＇s treatment were obviously lower than those before the treatment （P〈0.01） and the HDL-C absolutely increased after the 12-month＇s treatment （P〈0.01 ） in the research group. The values of TC, TG and LDL-C in serum a little increased comparing with the values before the treatment and the HDL-C had no significant changes in the control group. After the 6-month＇s or 12 month＇s treatment, the accumulative marks of carotid atherosclerosis plaque dropped in the research group and increased in the control group （P〈0.05） . Conclusion Using the Atorvastatin Calcium to lower the blood fat is effective, which can decrease and stabilize the carotid atherosqlerosis plaque, improve the carotid atherosclerosis and decrease the reoccurrence of ischemis stroke.