摘要
目的研究MMP-9和nm23在结肠癌中的表达及其与侵袭转移之间的关系，探讨MMP-9与nm23之间的相关性。方法采用免疫组化sP法对41例结肠癌和5例正常结肠组织做MMP-9和nm23的抗原标记。结果MMP-9和nm23的表达与淋巴结转移、分化程度、Duke’S分期有明显相关性（P〈0．01）；MMP-9和nm23的表达与结肠癌患者年龄、性别有明显相关（P〈0．01）；MMP-9与nm23在结肠癌的表达无相关性。结论MMP-9和nm23的表达与结肠癌侵袭转移密切相关，可作为判断结肠癌预后的指标。
Objective： To explore the correlation between the expression of MMP-9 and nm23 in human colorectal carcinoma and biological behavior, and evaluate the relationship between MMP-9 and nm23.Methods： The expression of MMP-9 and nm23 were detected in 41 cases colorectal carcinoma and 5 cases normal tissue by immunohistochemical SP method. Results： The expression of MMP-9 and nm23 was significantly associated with differentiation, Duke＇s stage and lymph nodes metastasis. The expression of MMP-9 was not correlated with nm23 in colorectal carcinoma. Conclusion： The expression of MMP-9 and nm23 significantly correlated with biological behavior of colorectal carcinoma, may be a better target of prognostic marker in human colorectal carcinoma.
关键词
基质金属蛋白酶9
转移抑制基因23
侵袭转移
Matrix metalloproteinases （MMPs）
Non-metastatic gene 23 （nm23）
Invasive
Metastasis
