脓毒症诱导急性肾损伤的研究进展

Research progress of acute kidney injury induced by sepsis

脓毒症是一种发病急、病情进展迅速、病死率高的危重疾病，急性肾损伤（AKI）被认为是预测脓毒症患者死亡的独立危险因素，但脓毒症诱导AKI的机制并不十分清楚。另外，RIFLE标准中的血清肌酐增加和尿量减少已经使我们能够在相对早的阶段诊断AKI，中性粒细胞明胶酶相关载脂蛋白（NGAL）作为肾损伤的一种早期标志物，在诊断及早期治疗干预中可能发挥潜在的作用。本文在此对脓毒症诱导的AKI发病机制、早期诊断及生物学标志物的研究进展做一探讨。

Sepsis is an urgent which rapid -developing critical disease with high mortality. Acute kidney injury（AKI） has been considered to be independent risk factor for predicting death in these patients, mechanism of AKI induced by sepsis is not fully clear. In addition, serum creatinine increase and urin output reduction in the RIFLE criteria have enabled us to diagnose AKI in its relatively early stages, neutrophil gelatinase associated lipocalin （NGAL）, an early biomarker of renal injury, would play a potential role not only in diagnosis but also in earlier theraputic interventions. This paper will review the research progress on mechanisms, early diagnosis and biomarker of AKI induced by sepsis.