高分子辅助的纳米粒子造影增强材料

Polymer-assisted nanoparticulate contrast-enhancing materials

纳米技术和纳米医学的研究在生物医学、疾病诊断和治疗方面显示出了巨大的应用潜力.有机荧光分子基检测技术已被广泛的用作造影和信号转换的工具用以测定痕量的分析物.然而,有机荧光分子基团的降解、光漂白作用使得其荧光的稳定性受到影响,从而限制了它们在复杂的生理环境中的应用.无机纳米粒子因其形状、尺寸和组成的不同而具有独特且稳定的光、电、磁及催化性能,可用作新型的生物纳米造影材料,能很好的解决造影检测技术所面临的难题.并且,纳米造影材料的表面修饰则可以提高它们的在生理条件下的稳定性和靶向生物活性分子的能力.

The application of nanotechnology to medicine research has enormous potential in modern biomedical research,disease diagnosis and therapy.Organic fluorophore-based detection techniques have been widely used as imaging and signal transduction tools for the detection of trace levels of analytes.The photosensitivity of the fluorophores,however,limits their application in complex environments,such as living bio-systems where degradation or photobleaching can occur.Inorganic nanoparticles have unique and stable optical,electrical,magnetic and catalytic properties because of their various shape,size and composition.The potential of the polymer-modified nanoparticles as novel imaging agents has been studied as a possible solution to this problem.In addition,surface modification of inorganic nanoparticles can enhance their biostability in physiological condition and ability of targeting bioactive molecule.