辛伐他汀对急性冠状动脉综合征患者血清妊娠相关蛋白-A和高敏C-反应蛋白的影响

Effect of Simvastatin on pregnancy-associated plasma protein-A and high sensitive C-reactive protein in patients with acute coronary syndrome

目的探讨辛伐他汀对急性冠状动脉综合征(ACS)患者血清妊娠相关蛋白-A(PAPP-A)和高敏C-反应蛋白(hs-CRP)的影响。方法ACS患者80例,随机分为辛伐他汀组(40例,常规治疗加辛伐他汀)和对照组(40例,常规治疗),治疗前和治疗1周后分别测定2组治疗前后外周血PAPP-A、hs-CRP水平,采用酶联免疫吸附法检测PAPP-A,散射比浊法检测hs-CRP。结果治疗前2组ACS患者血清PAPF-A、hs-CRP水平比较差别无统计学意义(P>0.05);与治疗前比较,治疗后辛伐他汀组和对照组PAPP-A和hs-CRP水平降低,差别均有统计学意义(P<0.01,P<0.05);治疗后辛伐他汀组患者血清PAPP-A和hs-CRP水平均明显低于对照组,差别有统计学意义(P<0.05)。结论辛伐他汀可降低ACS患者血清PAPP-A、hs-CRP水平,其稳定斑块的作用可能与抑制这些炎症因子的作用密切相关。

Objective To explore the effect of Simvastatin on pregnancy-associated plasma protein-A（PAPP-A） and the high sensitive C-reactive protein（hs-CRP） in patients with acute coronary sydrome（ACS）.Methods Eighty patients with ACS were randomly divided into Simvastatin group（n = 40,conventional therapy plus Simvastatin） and control group（n = 40, conventional therapy）.The levels of PAPP-A were detected by enzyme-linked immune sorbent assay（ELISA） and hs-CRP levels were detected by scatter turbidimetry method before and after 1 week＇s treatment.Results Before treatment,there were no statistic difference of PAPP-A and hs-CRP levels between two groups（P0.05）.Compared with before treatment,the levels of PAPP-A and hs-CRP were significantly lower in Simvastatin group and control group after treatment（P0.05 ）.After treatment, the levels of PAPP-A and hs-CRP in Simvastatin group were significantly lower than those in control group（P0.05 ）. Conclusion Simvastatin can decrease the levels of PAPP-A and hs-CRP in patients with ACS.It demonstrated that effect of Simvastatin can stabilize the vulnerable plaque are associated with decreasing PAPP-A and hs-CRP levels.