溴氰菊酯亚慢性染毒对小鼠学习记忆功能的影响

An experimental study on learning and memory functions of mice with subchronic poisoning by deltamethrin

目的探讨溴氰菊酯亚慢性染毒对小鼠学习记忆功能的影响及意义。方法按确定的溴氰菊酯高、中、低染毒剂量，对小鼠进行灌胃染毒，染毒时间为30d。对染毒后小鼠进行Y型臂迷宫试验和跳台试验。结果Y型迷宫试验巾，高剂量染毒组、中剂量染毒组、低剂量染毒组的总电击时间分别为（39．10±16．21）s、（34．54±12．19）s、（28．99±11．72）s，总训练次数分别为（70．35±28．07）次、（66．24±27．10）次、（60．58±23．49）次，错误反应次数分别为（34．89±14．64）次、（31．31±11．29）次、（28．62±9．28）次。与对照组比较，高剂量染毒组总电击时间延长，总训练次数、错误反应次数增加，正确反应率下降，均差异有显著性（P〈0．05，P〈0．01），中剂量染毒组除总训练次数外，其余各指标也差异有显著性（P〈0．05，P〈0．01）。与对照组比较，高剂量染毒组、中剂量染毒组染毒后跳台试验错误潜伏期显著缩短、错误次数显著增多、电击时间显著延长，均差异有显著性（P〈0．05，P〈0．01），低剂量染毒组染毒后错误次数显著增多，差异具有显著胜（P〈0．05）。

Objective To study the learning and memory functions of mice with subchronic poisoning by dehamethrin. Methods Mice were randomly divided into high-dose poisoning group, middle-dose poisoning group and low-dose poisoning group with different poisoning doses of deltamethrin by mouth for 30 d. After poisoning, the Y model maze test and diving tower test were carried out in each group. Results In the learning test of Y model maze test, the total electric shock period were （39.10 ± 16.21 ）s, （34.54 ±12.19）s and （28.99 ± 11.72 ） s, the total training times were （ 70.35 ± 28.07 ） times, （ 66.24 ± 27. 10 ） times and （ 60.58 ±23.49 ） times, and the error reaction times were （34.89± 14.64） times, （31.31 ± 11.29） times and （28.62 ±9.28） times, respectively in high-dose poisoning group, middle-dose poisoning group and low-dose poisoning group. Compared with control group, the total electric shock period, the total training times, the error reaction times of and the rate of right reaction in high-dose poisoning group and middle-dose poisoning group（ except for the index of the total training times in middle-dose poisoning group） increased significantly （ P〈 0.01, P〈 0.05） In the diving tower test, compared with control group, the error latent period shortened and the error times and total short electric shock periods increased significantly in high-dose poisoning group and middle-dose poisoning group（ P 〈 0.01, P 〈0.05）. Conclusion Subchronic poisoning by dehamethrin could result in decrease of the learning and memory functions of mice.