摘要
目的研究乌司他丁对体外循环术中肺脏的保护作用。方法选择心脏直视手术患者60例,分别设乌司他丁治疗组和对照组各30例,在5个时间点分别检测中性粒细胞弹性酶(NE)、白介素(IL)-8、超氧化物歧化酶(SOD)含量的变化。结果在主动脉开放后的3个时间点两组数据具有显著性差异。结论乌司他丁在体外循环中具有抗蛋白酶分解、调节细胞因子和减少氧自由基的肺保护作用。
OBJECTIVE To research the lung protective effect of Ulinastatin during extracorporeal circulation （ECC）. METHODS 60 patients undergoing open -heart surgery with ECC divide into two groups equally： Ulinastatin group and control group. NE.IL -8 and SOD＇levels were determined on 5 time points in each group. RESULTS The two groups had significant difference on 3 time points after opening aorta. CONCLUSION Ulinastatin has the ability of lung protective effect during ECC in three crucial aspects.
出处
《中国体外循环杂志》
2010年第1期37-38,共2页
Chinese Journal of Extracorporeal Circulation
基金
2006年江西省卫生厅课题(20061016)
关键词
乌司他丁
体外循环
肺保护
Ulinastatin
Extracorporeal circulationn
Lung protectio
