乳腺癌组织芯片中Survivin的表达及与临床病理特征和预后的关系

The expression of Survivin and its implication to clinic pathology and prognosis in breast cancer tissue microarray

目的探讨Survivin在乳腺癌组织芯片中的表达及其与患者临床病理特征和预后的关系。方法免疫组化S-P法检测80例乳腺疾病（乳腺良性增生18例和乳腺癌62例）标本组织芯片中Survivin蛋白的表达，并探讨其与患者组织学分级、临床分期和淋巴结转移等临床病理特征和预后的关系。并取20例癌旁正常组织作对照。结果正常乳腺、乳腺良性增生及乳腺癌组织中Survivin的阳性表达率分别为0（0／20）、33．3％（6／18）和72．5％（45／62），Survivin在正常乳腺、乳腺良性增生及乳腺癌组织中的表达呈逐渐增高趋势（x^2=34．62，P〈0．01）。乳腺癌组织中Survivin的表达与临床分期、淋巴结转移和生存年限相关（r=0．452，0．502，-0．423，P〈0．05或P〈0．01），与组织学分级无关（P〉0．05）。结论Survivin蛋白在乳腺癌发生、发展不同阶段的表达呈进行性上升趋势，Survivin蛋白可促进乳腺癌细胞的侵袭、转移等活动，与患者的预后密切相关。

Objective To investigate the＇expression of Survivin in breast cancer tissue microarray, and its implication to clinic pathology and prognosis. Methods The expression of Survivin was studied in 80 cases of breast disease tissues （ 18 cases of hyperplasia of mammary glands and 62 cases of breast cancer） and 20 cases of adjacent normal tissues by S-P immunohistochemisty to analysis the relationships between its expression and history grade, clinic stage and lymphaden metastasis. Results The positive rates of Survivin were 0（0/20） in normal mammary glands, 33.3% （6/18） in hyperplasia of mammary glands and 72. 5% （45/62） in breast cancer. There were significant difference between them （X^2 = 34. 62, P 〈 0. 01 ）. The expression of Survivin was closely correlated to the stage and lympbaden metatasis and survival time （ P 〈 0. 05 or P 〈 0. 01 ）, and it was negatively correlated to the histological grade （ P 〉 0. 05 ）. Conclusions The expression of Survivin shows an ascending tendency in the carcinogenesis and progres- sion of breast cancer. The Survivin can promote the invasion and the metastasis of the cancer cell, and it is closely correlated to the prognosis.