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FHL-1及FHL-2在胃癌组织中的表达及其临床意义 被引量：1

The expressions of FHL-1 and FHL-2 and their significance in gastric cancer
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摘要 目的检测FHL-1及FHL-2在胃癌组织中的表达情况,探讨FHL-1及FHL-2与胃癌相关临床病理因素的关系。方法采用免疫组化SP法检测35例胃癌和20例切缘正常组织中FHL-1及FHL-2表达。结果FHL-2蛋白在胃癌组织及正常胃黏膜组织中的阳性表达率分别为88.57%、20%,两者之间差异有统计学意义(P<0.05),且表达程度与临床病理因素无明显相关性(P>0.05)。FHL-1蛋白在正常组织及胃癌组织中阳性表达率分别为80.00%、34.29%,两者比较差异有统计学意义(P<0.05)。结论FHL-1和FHL-2可能在胃癌的发生、发展过程中起着重要的作用。 Objective To detect the expreesions of FHL-1 and FHL-2 in gastric cancer and to explore the relationship between the expressions of FHL-1 and FHL-2 and clinicopathological factors of gastric cancer.Methods Immunohistochemistry staining was used to detect the expressions of FHL-1 and FHL-2 in 35 cases of gastric cancer and 20 cases of normal tissues.Results In gastric cancer group and normal tissue group,the positive expreesion rates of FHL-2 were 88.57% and 20% respectively.There was statistically significant difference between the two groups（P0.05）.The expression of FHL-2 in gastric cancer was not related to clinicopathological factors（P0.05）.The positive expression rates of FHL-1 were 80.00% and 34.29% respectively in normal tissues and gastric cancer tissues.There was significant difference between the two groups（P0.05）.Conclusion FHL-1 and FHL-2 may play an important role in the early gastric tumorigenesis and progression.
作者 杨梅 操寄望
机构地区 武汉大学第一临床学院消化内科
出处 《胃肠病学和肝病学杂志》 CAS 2010年第3期213-215,共3页 Chinese Journal of Gastroenterology and Hepatology
关键词 FHL-1 FHL-2 胃癌 免疫组化 FHL-1 FHL-2 Gastric cancer Immunohistochemistry
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献14

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二级参考文献23

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共引文献1

同被引文献10

  • 1周江,徐峰,张海涛.影响胃癌临床预后的多因素分析[J].苏州大学学报（医学版）,2005,25(3):494-494. 被引量：25
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胃肠病学和肝病学杂志
2010年 第3期

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