摘要
目的检测FHL-1及FHL-2在胃癌组织中的表达情况,探讨FHL-1及FHL-2与胃癌相关临床病理因素的关系。方法采用免疫组化SP法检测35例胃癌和20例切缘正常组织中FHL-1及FHL-2表达。结果FHL-2蛋白在胃癌组织及正常胃黏膜组织中的阳性表达率分别为88.57%、20%,两者之间差异有统计学意义(P<0.05),且表达程度与临床病理因素无明显相关性(P>0.05)。FHL-1蛋白在正常组织及胃癌组织中阳性表达率分别为80.00%、34.29%,两者比较差异有统计学意义(P<0.05)。结论FHL-1和FHL-2可能在胃癌的发生、发展过程中起着重要的作用。
Objective To detect the expreesions of FHL-1 and FHL-2 in gastric cancer and to explore the relationship between the expressions of FHL-1 and FHL-2 and clinicopathological factors of gastric cancer.Methods Immunohistochemistry staining was used to detect the expressions of FHL-1 and FHL-2 in 35 cases of gastric cancer and 20 cases of normal tissues.Results In gastric cancer group and normal tissue group,the positive expreesion rates of FHL-2 were 88.57% and 20% respectively.There was statistically significant difference between the two groups(P0.05).The expression of FHL-2 in gastric cancer was not related to clinicopathological factors(P0.05).The positive expression rates of FHL-1 were 80.00% and 34.29% respectively in normal tissues and gastric cancer tissues.There was significant difference between the two groups(P0.05).Conclusion FHL-1 and FHL-2 may play an important role in the early gastric tumorigenesis and progression.
出处
《胃肠病学和肝病学杂志》
CAS
2010年第3期213-215,共3页
Chinese Journal of Gastroenterology and Hepatology