壳聚糖纤维/磷酸钙骨水泥复合材料人工骨的降解性能

Degradation Behavior of Chitosan-fiber/calcium Phosphate Cement Composite for Artificial Bone

提出添加壳聚糖纤维改善自固化磷酸钙骨水泥的降解性能。根据单一材料均匀降解假设和狗股骨远端松质骨区缺损修复试验研究壳聚糖纤维/骨水泥复合材料人工骨的降解性能。理论分析发现添加的纤维使得人工骨降解量与时间呈现非线性的二次函数关系;纤维质量分数的增减是人工骨降解率的关键影响因素。骨缺损修复试验结果显示人工骨残留材料率与时间形成高阶函数关系,且其试验曲线与骨组织工程理想曲线相似。分析认为,壳聚糖纤维降解速度高于骨水泥造成人工骨在缺损修复的过程中出现多孔结构,进而在促进新生骨组织生长的同时改变了该人工骨的降解规律,结合纤维质量分数的控制,有可能使人工骨的降解速率与骨组织生长相匹配。

To imporve the biodegradability of self-setting calcium phosphate bone cement （CPC） adding chitosan fibers （CF） is proposed. The degradability of CF/CPC composite artificial bone is reasearched on the basis of single biomaterial equal-degradation- rate hypothesis and the canine condyle defect repairing experiment. Theoretical analysis finds that the existence of fiber makes the degradation function of CF/CPC artificial bone quadratic rather than linear, and the degradation ratio can be controlled by changing CF content in composite artificial bone. In vivo experiment shows that the remainder law of artificial bone is one of high-order functions, similar to the ideal remainder curve for bone tissue engineering scaffold. Higher degradation rate of CF than CPC leads to the formation of macroporous structure inside the CF/CPC artificial bone, which further promotes new bone growth and bone reconstruction, and by regulating the CF content, the degradation rate of CF/CPC artificial bone can well match the bone regeneration.